Furthermore, a significant trend toward worse survival was found in the high-risk group ( p = 1.495 × 10 − 7 ).
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Although they did not survive false discovery rate correction (FDR) for multiple testing (Additional file 1 : Table S3), the nominally significant pairwise comparisons showed enrichment for π c differences related to hematological and metabolic traits (hematological fold-enrichment = 4.45, p = 2.15 × 10 –7 ; metabolic fold-enrichment = 4.05, p = 4.01 × 10 –6 ).
27 Although the published FSHB promoter polymorphism was not the strongest signal in this region, it was genome-wide significant for association with LH in our data ( P= 4.84 × 10 −9 ), and nearly significant for FSH ( P= 2.31 × 10 −7 ) ( Supplementary Table 11 ).
The GOEAST analysis only reveals some slightly significant overrepresented GO-terms, as, for example, the Molecular Function alpha-glucosidase activity ( P -value = 2.91E −7 ).
Several immuno-active genes demonstrated highly significant correlations between methylation and gene expression in IBD, in particular OSM: IBD r = −0.32, p = 3.64 × 10 −7 vs non-IBD r = −0.14, p = 0.77].
As expected from the relationship between plant times and theta sequences, there was a highly significant temporal modulation of MUA and plant times (5 rats, 61 epochs, 60–100 cm on w-track: t -test: P = 3.9 × 10 −7 ; Extended Data Fig. 4c ).
Similarly, of the 17 genes in the “Chondroitin sulfate metabolic process,” which was highly significant in the ethanol-upregulated genes in the IP fraction ( p = 5.26 × 10 −7 ), and all ethanol-regulated genes ( p = 8.69 × 10 −4 ), 16 were upregulated by ethanol, suggesting that this process was highly upregulated in ethanol-exposed astrocytes.
After removal of the data during the Covid pandemic, highly significant interactions were still detected between gender and mobility in first-time donations ( p = 6.2e-07) and between gender and age group in repeat donations ( p < 2.2e-16) ( Supplementary Table S3 ).
Our custom pathway enrichment (comprising Gene Ontology and KEGG databases) analysis of the impacted genes within the CNV breakpoints of all pathogenic deletions identified “ubiquitin-like protein transferase activity (GO:0019787),” “negative regulation of cell death (GO:0060548),” and “vesicle-mediated transport in synapse (GO:0099003)” pathways to be highly significant (FDR p < 6.53 × 10 −7 , FDR p < 7.2 × 10 −6 , and FDR p < 7.1 × 10 −5 ) after correction for multiple tests ( Figure 3A ).
9, cg22581270 in CASP16P, and cg14485214 in SNED1 were highly significantly associated with BMD ( p < 7.0e−07, FDR < 4.7e−05) (Additional file 4 : Table S2).
Table S2 shows that the odds ratio (OR) increased from 0.8851 to 0.9323, and the corresponding p -values changed from highly significant ( p = 7.15 × 10 −7 ) to non-significant ( p = 0.136), implying that the relationship between DASH score and HTN may be partially mediated by obesity.
Leptin levels were measured in both peripheral blood and bone marrow plasma from 8 of the patients and three elderly controls, and we found a highly significant correlation between leptin levels measured in the two compartments ( R = 0.97, p = 7.4 × 10 –7 , Additional file 2 : Fig.
In contrast, CSA knockout led to strong decrease of the EGFP expression in comparison to the parental cell line, which was highly significant for both cyclo-dA stereoisomers ( P = 9.0 × 10 −7 for 5′ R - and P = 8.5 × 10 −7 for 5′ S -cyclo-dA, heteroscedastic Student's t -test).
Note that the difference in PS rates is highly significant ( P < 10 −6 ). 10 μg of protein isolated at 1 h was processed by 8%PAGE/SDS for fluorographic auradiography with PPO.
Convergence was obtained for all morphological traits and in all cases the full model accounted for significantly more variance than the constants-only model and this difference was highly significant ( P < 10 −6 ).
In Supplementary Data 6 , the association of CHRM3 activation with “urinary contraction” (literature ID 364) contains the p value and ROC AUC for “Urinary retention” and is classified as highly significant ( p ≤ 1e-06), with distance 1 (i.e., the significant PT and starting PT are connected via 1 intermediate in the network, via the shared HT).
3 Results 3.1 Nutrient main effects The overall mean effect of P was found to be highly significant (p < 1e −6 ) with an average yield gain of 251 kg ha −1 at an average rate of 15 kg P ha −1 .
Within these 47 regions, we also assessed whether the traits that did not have a variant with p < 5 x 10 − 8 , had a moderately significant variant with p < 1 x 10 − 6 ; signals from such traits were also included in our fine-mapping.
Twenty-five additional independent loci showed moderately significant ( P < 1 × 10 −6 ) associations, nine with endometrial cancer overall, nine specifically with endometrioid histology, and seven with non-endometrioid histology (Supplementary Data 2 ).
For BRCA2 both ER and grade were highly significant predictors of mutation status, and the interaction of ER and grade was also quite significant (χ 2 = 28.3, 2 df , P <10 -6 ).
In all instances, the herd random effect was highly significant ( p < 10 −6 ), indicating a strong herd effect on the probability of Map shedding.
4.2.2 Performances of AEVA‐HE versus DermaTOP in study 2 When focusing on the crow's feet region extracted from both systems, using the same region of interest dimensions, comparable and highly significant results are obtained (Figures 12 , 13 ). “Sa” roughness parameter, ( r = 0.88) and for mean depth parameter ( R = 0.93) with p < 0.000001 in both cases.
These differences were quite significant ( p < 1.7 × 10 −6 ) for every five participants.
However, it was highly significant on the individual level with greater power (B = 5.4, p = 2 × 10 –6 ), suggesting that in Eastern Hungary the trend of respondents in larger settlements having later chronotypes is amplified.
Notably, 8 of these 12 genes ( ENO2, LUC7I3, KIF21A, MAP4K4 , PPP3CA, MACF1, NDRG4, and PRRC2C ) were differentially spliced in 12-month-old Trem2*R47H mice, which was highly significant (hypergeometric p = 2.78 × 10 –6 ) (Table 3 ).