Excerpts

The mean Pearson correlation between speed and HθWP after SAL and CNO injection were 0.44 ± 0.04 and 0.36 ± 0.07, respectively, reflecting a highly significant correlation in both cases (mean p < 10 −39 ).

There was a highly significant trend in increased risk associated with BMI categories of ≥25 to <30 and ≥30 ( P = 1.4 × 10 −39 ).

RNA sequencing and allele expression imbalance (AEI) analysis of OS and matched healthy control samples revealed a highly significant AEI ( p = 2.14 × 10 −39 ) for SNPs in the BIRC3-YAP1 locus on pig chromosome 9.

A highly significant reduction ( p = 2.3 × 10 –39 ) in the number of Candida colonies was observed in the treatment arm when comparing pre- and post-study results.

The total GRS based on 80 known index SNPs showed a highly significant association with T2D (OR 1.07 [95% CI 1.06–1.08] per risk allele; P = 2.31 × 10 −39 ) ( Table 2 ).

Comparison of mean firing rates of responsive single neurons for the best location of each neuron in each training phase, after subtracting baseline activity, revealed a highly significant difference between stages (Fig. 3b ; 1-way ANOVA test, F 3,531 = 72.4, p = 2.87 × 10 −39 for the cue period, F 3,531 = 21.93, p = 2.12 × 10 −13 for the first delay period).

There was a highly significant correlation between relative amounts estimated based on OTU counts and on raw reads data (Pearson c = 0.9947; p = 3∙10 −39 ; Supplementary Figure 3 ).

falciparum ’s large proteins displayed unique and parasite-specific annotations, with a highly significant presence of host cell binding functions ( P = 3.21e−39) compared to the rest of the proteome.

The results of the test were highly significant ( P = 3.41 × 10 −39 ; Fig. 4c, d ), proving that there is a strong relationship between the data-driven GGM and the known IgG glycosylation pathway.

S4b ), we found a highly significant peak on chromosome 17 (Fig. 6a , Supplementary Data 5 and 6 ) where the lead variant was an intergenic SNP upstream of the BMP2 gene (chr17:15643342:C>T, P = 3.45 × 10 − 39 ).

IPA upstream analysis estimated module-specific upstream regulators, including transcription factors (Table S2 ), and suggested that the transcription factor MITF was activated in co-module #12, which was highly significant among co-modules (IPA overlap p-value = 6.91E-39, Fig.

This correlation was highly significant ( Fig 5B ; P value = 7.1x10 -39 ; linear regression), suggesting that the variation in additive effects of polymorphisms across the 20 environments, rather than the effect size, was associated with the changes in activity of interactions in the epistatic network.

Remarkably, 35 insertions are located at common insertion sites (CISs), a highly significant result (Fisher's exact test p = 7.4×10 −39 ) ( Table 1 ).

These results were corroborated by the analysis of functional pathways using the ConsensusPathDB 25 (Methods); gene sets showed highly significant overlaps ( P <7.66 × 10 −39 –2.38 × 10 −05 ) with pathways involving OR and GPCR-related signalling and signal transduction, (extra-cellular matrix related) processes of inter-cellular communication, immunoregulatory processes and membrane-linked drug transport.

there was a highly significant correlation between measurements of macrophage infiltration and SAMD9 expression in LGG ( Figure 7C ) (partial.cor = 0.551, p = 7.78E-39).

4c ) show that the TE and ICM nuclei in blastocyst embryos have highly significant differences in the mean nuclear dry mass density ( p -value = 8.11e−39), while the differences for cleavage state embryos are nonsignificant ( p -value = 0.0105).

Using a logistic regression model, we found that several factors had a highly significant influence on whether a proximal eQTL was detected as an aiQTL; namely, the distance of the eQTL from the TSS (P = 1 × 10 − 38 ), the number of samples with more than one allele-specifically mapped read (P = 1 × 10 − 88 ), the log P value of the eQTL (P = 3 × 10 − 174 ), the minor allele frequency of the eQTL (P = 2 × 10 − 44 ) and the median number of allele-specifically mapped reads (among samples with more than one allele-specifically mapped read; P = 0.008).

To further investigate the significance of these directional findings we estimated the differences in the slopes using z-scores and demonstrated that for 31 of the 35 genes the differences were highly significant (Bonferroni corrected p<1×10 −38 ) ( Supplementary Table 4 ), thus strongly suggesting these were not chance observations.

Interestingly, in a joint model where both rs970740 and rs6025 were used as covariates for predicting cg16548605 variability, the effect of rs970740 was highly significant (p = 1.05×10 −38 ) but that of rs6025 was not (p = 0.90).

Similarly, Table 4 reveals a highly significant effect of elevation height on PV efficiency (F = 134.21, p = 1.31 × 10– 38 .

GO enrichments for the lightgreen module are highly significant for “secretory granule” (p=2.14E-38), “secretory vesicle” (p=1.96E-36), and different specific neutrophils-associated terms such as “neutrophil activation involved in immune response” (p=1.04E-35), “neutrophil degranulation” (p=1.04E-35), “neutrophil activation” (p=2.00E-35), and “neutrophil mediated immunity” (p=2.64E-35).

We measured the relative abundance of the total ether-linked lipids and observed a highly significant elevation ( p -value = 2.94E-38) of total ether-linked lipids at 48 h post virus infection ( Figure 5C ).

While the small (∼5 nm) difference between the early and late S-phase distributions is statistically highly significant (Kolmogorov–Smirnov test, P = 3e-38), it is unlikely that, given the ∼30-nm standard deviation of the individual distributions, this difference has biological significance.

The ISR total change included 7259 patients and showed a highly significant trend in an F statistic versus constant model with F = 169, p = 3.13 e − 38.

Module detection followed by a meta-analysis on chronological age identified fifteen consistently coexpressed PPI modules associated with chronological age, including a highly significant module ( P = 3.5 × 10 −38 ) enriched for ‘ T-cell activation ’ marking age-associated shifts in lymphocyte blood cell counts ( R 2 = 0.603; P = 1.9 × 10 −10 ).