Excerpts

The most highly significant variant at 5q33.1 (rs17728338) shows opposing effects on AD and psoriasis (MNM p = 3.96 × 10 −38 ; Table S5 ) and lies 2 kb upstream of ANXA6 (MIM 114070 ) and 8 kb downstream of TNIP1 (MIM 607714 ).

In addition, a highly significant number of these genes have a SMARCB1 ChIP-seq peak ( p -value = 5.43e −38 , Fig. 5b ), confirming that genes regulated by SWINGN share their regulation with SWI/SNF.

A highly significant S-PrediXcan signal ( p = 6.10e–38) was also obtained for this WDR19 intron cluster in testis, however the evidence for colocalization with the GWAS peak was low (PP.H4.abf = 0.39).

The QPHSg.wsu-2D locus was highly significant in this GWAS (7.64 < –log 10 ( p ) < 37.13), and had strong effects (0.02 to 0.72).

We observed a highly significant correlation ( R 2 = 0.5086, p = 8.5e−38; data not shown).

The difference was highly significant (Mann–Whitney p = 1.0E–37); (2) location of matching regions: In non-seed-binding miRNAs/isomiRs, we observed that over half of the matching regions began between positions 6 and 8.

Genes overexpressed in old but not young Nrg1 tg-type I mice (Supplementary Table 3 ) included many with immune and inflammatory functions, and IPA generated two highly significant networks ( p = 10 −37 and p = 10 −34 ; one is shown in Fig. 1e , the other in Supplementary Fig. 4 ).

Overall, we observed a modest (R = 0.21) but highly significant (p=1e-37) correlation between the mislocalization of genes in the CAD knockout system and the mislocalization of their human orthologs in the FXS iPS system ( Figure 3—figure supplement 5 , Supplementary file 1b ).

In contrast, subtle but highly significant differences were evident between the velocity profiles of correct and incorrect saccades at long rPTs (mean peak velocity, correct versus incorrect: monkey R, p = 10 −37 ; monkey T, p = 10 −50 ; monkey G, p = 10 −27 ; Wilcoxon rank-sum test; Fig. 2c ).

58 Variations in the gene encoding glutamate decarboxylase-like protein 1 (GADL1) were found to be associated with response to lithium with an extraordinarily highly significant P value (P=10 37 ).

Examination of the proteins with reduced abundance in the sod-1 mutant showed a highly significant enrichment of ribosomal proteins ( p < 10 –37 ) including 24 RPL proteins, which are in the large 60S ribosomal subunit ( Figure 6 C, Table S6 ).

Indeed, comparison of the 500 strongest peaks and 500 hottest hotspots revealed a highly significant correlation ( Figure 3C , p<10 −37 ).

The Jaccard similarity coefficients and the highly significant p -values (hypergeometric test p < 1 × 10 −37 in all cases) of the overlap of the top upregulated genes in DN and the GNs indicated that upregulated genes were common not only among FSGS, MN and IgAN, but also among DN and the three GNs ( Figure 1B ).

Another study [ 8 ] reported that infection rates are higher in metropolitan cities with large population density in India as they found a fair and highly significant correlation ( r = 0.49, p-value ~ 10 −37 ) at the 5% level of significance.

In fact, χ 2 test of independence of the three stresses is highly significant (χ 2 = 179.39, df = 4, p = 1.01e −37 ), suggesting that the three stresses indeed induce common epigenetic changes in A. thaliana .

When we compared these normal HSC commitment-associated DMRs with the DMRs identified in Satb1-deficient HSCs, we found a highly significant overlap (p=1.2×10 −37 ; hypergeometrical testing), with 37% shared hypermethylated DMRs and 15% shared hypomethylated DMRs (overall 22% shared DMRs) ( Supplementary Fig. 6e ).

The GICC GWAS meta‐analysis result for rs3761124 was highly significant (β = .29 (.02), p = 1.3E ‐37 ).

Fraction Csp3 showed highly significant correlations with Molar Refractivity (p = 1.7613E-37), MolVol (A3) (p = 4.2254E-26), and Druglikeness score (p = 9.35371E-33), while exhibiting marginally significant associations with TPSA(Å 2 ) (p = 0.059100432) and MolPSA (A2) (p = 0.055785406).

For the total number of virulence genes per genome, the difference between ST2250 ( n = 205) and non-ST2250 ( n = 107) genomes remained highly significant ( p = 1.87e − 37, Mann–Whitney test).

NORM ( P = 2.03E-05 in SM and P = 4.84E-06 in SM1), compared with highly significant results in the basic model of the nontargeted analyses ( P = 2.01E-37).

Afterwards, association signals from joint analyses of the 2 datasets ( Table 2 ) consistently showed highly significant association for HLA-DQB1 (P = 2.33×10 −37 ), PSORS1C1 (P = 5.70×10 −10 ) and TNIP1 (P = 4.68×10 −9 ), and also showed some evidence of association for RHOB (P = 3.17×10 −6 ).

Of course, with such huge sample sizes, the difference turned out to be highly significant statistically (Kolmogorov–Smirnov test, P = 4 × 10 −37 ).

The biomarker-derived risk score demonstrated independent prognostic value in CGGA-693 (multivariate Cox hazard ratio = 9.195; p < 0.001) after adjustment for WHO histological grade, with Kaplan–Meier analysis confirming highly significant survival separation (log-rank p = 4.60 × 10 −37 ).

Our results ( Figure 5b ) show a highly significant correlation (Fisher's exact test: p -value < 1*10 −36 ) between a nearby marking event and the decision to remove the adjacent bead. 3.5 The effect of pheromone marks and recruitment on context sensitivity Since pheromone markings act as triggers for the clearing behavior, we tested whether the marking rates could explain the context sensitivity described above (Methods and Figures 3d – g ).

The average sum is much smaller for Model 1 than for Model 4 and the differences between natural and simple design are highly significant (p<10 −36 , Welch's t -test).