Excerpts

The addition of the FHS gave a highly significant improvement to risk models containing binary family history ( P < 0.001), the number of relatives with breast cancer ( P = 0.001), the type of relative with breast cancer ( P < 0.001), and the age of relative at breast cancer diagnosis ( P = 0.01).

OSCC with lymph node metastasis showed only slight lymphoplasmocytic infiltration in a highly significant manner ( P < 0.001).

In the WDF versus YM comparison, nine significantly enriched pathways ( P < 0.05) and one highly significant pathway ( P < 0.001) were identified, with two enriched DEGs upregulated and 52 downregulated.

Table 3 shows that after controlling for these factors, the profile main effect remained highly significant for all nine subtests (all p < 0.001).

In this case, the regression between the base 10 logarithm of the amount of copies per milliliter and the number of infected individuals is highly significant (Y = 1.24 (±0.13) + 0.08 (±0.01)X; r2 = 0.81; F 1,12 = 50.8; P < 0.001).

The differences between the IFN treatment groups and NC group were extremely significant ( P < 0.001).

All regression analyses were highly significant ( p ≤ 001).

In accordance with previous studies, there was a highly significant inverse bivariate association of parental SEP with AL ( r = −.26, p < .001) (Additional file 3 : Table S2: Correlation matrix of all study variables).

The effect of time was highly significant ( p < 0.001), but, the difference between the versions was not.

Significant changes were observed in laboratory parameters of CRP, ESR (inflammatory markers), and AEC (allergic marker) when compared from baseline to28 day in HFUM treatment which was highly significant (P=<0.001).

When accounting for the interaction effect, the main effect of employment loses significance, indicating that employment alone does not significantly predict mental health when artistic leisure is considered as a moderator (AOR=0.65, 95% CI=0.32, 1.31, p =0.23), while the main effect of artistic leisure remains highly significant (AOR=0.10, 95% CI=0.05, 0.18, p <0.001).

Importantly, the interaction between treatment and time was highly significant ( F = 26.51, P < 0.001), indicating that the effect of treatment varied across the different time points.

The differences between individual mice were significant (p = 0.01) and highly significant between the counting methods (p < 0.001).

Exposure-dose (concentration × time, % h) showed a positive trend with ΔE00 (r=0.401, p<0.001; R 2 =0.161).

In these groups as well, sensitivity analyses excluding the year 2020 confirmed an increasing trend in sudden death–attributable mortality in both sexes [AAPC: +2.7% (95% CI: 1.8–4.0), p < 0.001 in men; and AAPC: +3.0% (95% CI: 2.0–4.5), p < 0.001 in women, respectively].

The likelihood-ratio test was highly significant for the total MFM and for all three domains ( P < 0.001), excluding the use of the rating scale model that assumes equivalent thresholds across all items.

Nominally significant DEGs with a p -value < 0.001 were used as the input for the gene set enrichment analyses using FUMA [ 31 ] and ShinyGO version 0.77, as well as for transcription factor binding site enrichment analysis using CiiiDER [ 32 ].

Results indicated a highly significant effect of material type on mass loss ( p < 0.001).

Nine genes from this training set were found to have an increased burden of novel damaging mutations in our ‘restricted-eating’ and ‘binge-eating’ groups representing a highly significant, more than four-fold enrichment for known ED genes (OR = 4.2, P< 0.001).

The permutation test produced highly significant results ( p < 0.001), thereby confirming that the model’s effectiveness significantly surpasses random chance.

Joint state was the most highly significant variable when analyzed independently, as well as with every other possible combination of variables included in the model ( P = 0.001).

Heterozygous (AC) carriers of the A1298C variant demonstrated highly significant protection against CRC development (RR = 0.2, p = 0.001), while a two-fold higher risk for CRC was estimated for homozygous genotype (CC) carriers.

In multiple regression analysis, regular use of any omega-3 fatty acid supplements was associated with a 16% (95% confidence interval: − 28- -5%), p = 0.006 decrease in ln-transformed delta CRP level as compared to subjects who reported no or sporadic use of omega-3 fatty acid supplements (Table 3 , Model 4). There was a highly significant increase in creatine kinase values following the race ( p < 0.001), but no difference between the different categories of supplement users (Supplementary Figure 2 ).

Trichosporiella exhibited a highly significant positive correlation with Apigenin ( P < 0.001), while Cadophora showed a highly significant positive correlation with Hyperoside ( P < 0.001).

The difference in length of stay (LOS) was equal to 10 days and was statistically highly significant ( p < 0.001).