Excerpts

The difference between these two slopes was highly significant ( t (72) = −11.5; p = 6.1×10 −18 ).

Whereas, RNA M of newly reported Chinese isolate YNKM-2 had one highly significant recombination event ( P -value = 6.586 × 10 − 18 ) spanning from 3111 to 3811 bp (without gaps), detected by seven algorithms i.e., RDP, GeneConv, Bootscan, MaxChi, CHIMAERA, SisScan, and 3SEQ.

Using this approach, we found that the positive association between CAI and logPPR was highly significant ( G = 72.977, df = 1, P = 1.31e-17).

The changes in AUC-ROC were not statistically significant (DeLong p -values of 0.922, 0.902, and 0.750 respectively); however, the McNemar test was highly significant ( p = 1.39 × 10 −17 , 5.23 × 10 −30 , 2.25 × 10 −24 ).

Accordingly, the removal of these functional factors leads to a highly significant association between GC content and recent positive selection (slope = 0.49; P < 1E−16; supplementary Results S3: table S4, Supplementary Material online).

The protein–protein interaction enrichment was highly significant ( p -values < 1.0 × 10 –16 ) for both #BiAll-93 and #MonoAll-2.13 (Supplementary Table 4a, b), and most of the proteins grouping together were linked to six distinct biological functions (Fig. 3 d–f). #BiAll-93 and #MonoAll-2.13 cells shared a cluster, representing the combination of four Gene Ontology (GO) terms that were associated to stress response, cell adhesion and proliferation, and processes of cellular and organismal development.

Figure 3 illustrates the interactome for DS3, featuring 257 edges, 57 nodes, an average node degree of 9.02, and a highly significant PPI enrichment p -value of <1.0 × 10 −16 .

The PPI network showed a highly significant enrichment with a p-value of <1.0e −16 and an average local clustering coefficient of 0.707.

DAPs Are Involved in Wound Repair and Blood Coagulation Are Associated with Hydration Protein–protein interaction analyses of DAPs using STRING [ 19 ] resulted in a highly significant clustering (PPI enrichment value of p < 1.0 × 10 −16 ) consisting of 34 nodes and 126 edges ( Figure 2 ).

There is a highly significant correlation between F ST and A ancestry difference between the lowland and highland samples (Spearman's ρ = 0.26, P < 10 −16 ).

Each result is highly significant ( p < 10 −16 , for each predictor.

This up-regulation was highly significant on meta-analysis (Fisher’s combined P = 1.4 × 10 −16 , Fig. 2C ).

The linear model is highly significant ( p -value < 2 × 10 − 16 ), and 62% of the ENL variance is explained by the time of development ( R a d j 2 ≈ 0.62 ), while the residuals of the model follows a normal distribution ( p -value 0.3375 in the Shapiro–Wilk test; see Supplementary SI.2 for details).

The Shetland Sheepdog ranked second in all models, and both Collies and Shetland Sheepdogs were highly significant according to the logistic regression model ( p < 2 × 10 −16 ).

Distance to the sea is also highly significant (R 2 = 0.47, p <2e -16 for Tajima’s D).

The above nearly significant interaction, when comparing the 50 vs. 100% treatments, is marginal in comparison to the differences in density across weeks ( z = −16.916, p < 2e-16).

Specifically, adjusting for African ancestry in a multiple regression model largely eliminated the highly significant effect of Black ethnicity on serum creatinine levels (decreased from P<2x10 -16 to a marginally significant P=0.05) whilst the highly significant effect of African ancestry on creatinine remained essentially unchanged when adjusted for Black ethnicity (P<2x10 -16 before and after adjustment).

Importantly, the interaction between category and location was also highly significant (β = .165, t = 9.386, p < 2e−16), indicating that the correlation between VWFA‐2 and the IFC was significantly stronger compared to the other ventral ROIs.

The effective degrees of freedom (edf) for the smoothing term were 8.918, and the corresponding F-statistic and p -value indicated that the smoothing term was highly significant ( p -value < 2e-16).

All p -values for the correlation coefficient are highly significant ( p -value < 2.0 × 10 −16 ).

After accounting for the general tendency for each participant to report higher or lower GAD-7 scores (Model 2), and adjusting for other covariates (Model 3), highly significant dose-response trends were evident (p < 2e-16 for each), adding 2–3 additional points to GAD-7 scores in highest categories of exposure ( Table 3 and S4 Table ).

The categorical, as well as the smoothed fixed, effects were all highly significant ( p < 2 × 10 − 16 ).

Across the 38 weeks of the study, the percentage of reactive cases per week showed an increasing trend (value of p < 2e-16), ranging from 0.4% (95% C.I.: 0.11–1.47%) in the second week to 41.9% (95% C.I.: 26.4–59.2%) in the last week ( Figure 1 ).

The statistical analysis showed a highly significant evolution of the sugar ( p < 2 × 10 −16 ) and starch ( p < 1.339 × 10 −5 ) curves in function of the reaction time.

When restricted to people of M/F gender and whose gender was identically recorded in both databases, forename mismatches occurred in 2.37% of females (1727/72,948) and 2.16% of males (1153/53,474), a small but significant difference ( χ 2 1 = 6.0909, p = 0.01359), while surname mismatches occurred in 6.78% of females (4947/72,958) and 2.22% of males (1185/53,484), a highly significant difference ( χ 2 1 = 1392.7, p < 2.2 × 10 −16 ).