“a decreasing trend”

Through trend test analysis, the clozapine serum concentration showed an increasing trend with increasing drug dose ( p < 0.001), and the C/D ratio showed a decreasing trend with increasing daily drug dose ( p < 0.001) (Table 3 ).

Similarly, in the MCDB cohort, patients’ prognoses showed a decreasing trend by the new pN classification (all P < 0.001, Fig. 4 C).

ACTH : it showed a decreasing trend during the profile in both conditions ( p = 0.001 placebo, p = 0.012 diclofenac) but at a direct comparison, the two trends did not show any significant difference (Table 1 and Supplementary Fig. 2 a-b).

coli isolates resistant to most of the antibiotic categories remained stable between 2015 and 2019, though a decreasing trend in the proportion of E. coli isolates resistant to fluoroquinolones (37.8–32.0%, p < 0.001) and aminoglycosides (15.6–11.9%, p = 0.002) was observed over time (Fig. 3 ).

In both groups individually, severity scores showed a decreasing trend, with more fall in scores at 12 weeks than at 24 weeks ( p < .001 for all comparisons on the Wilcoxon Signed Ranks test).

Questionnaires of Tinnitus Handicap Inventory (THI), Hospital Anxiety and Depression Scale (HADS) and Visual Analogue Scale (VAS) were used to evaluate the therapeutic effects and relevant factors affecting the efficacy of therapy. Results The results showed a decreasing trend in THI and VAS scores after 3 months of therapy, with statistically significant differences between pre- and post-therapy time points ( P < 0.001).

However, the consumption of refined grains in higher quartiles showed a decreasing trend ( p < 0.001).

The rate of HAIs (from 31.83 per 1000 patient-days in 2012 to 9.72 per 1000 patient-days in 2019) and the adjusted rate of HAIs (from 9.07 per 1000 patient-days in 2012 to 2.47 per 1000 patient-days in 2019) all showed a decreasing trend year-on-year from 2012 to 2019 ( P < .001; Table 1 ). 3.2.

Annual crime rates for the 2009–2016 period show a decreasing trend in both the general population (IRR=0.981 (95%CI=0.978–0.983) p<0.001) and in patients with FEPs (IRR=0.019 (95%CI=0.012–0.028) p<0.001); this pattern is more pronounced the FEP group.

Periodontal Severity and COPD Exacerbations Figure 2 shows the association between lung function parameters (post-bronchodilator FEV 1 percent predicted, FVC percent predicted, and FEV 1 /FVC ratio) and periodontitis severity, which showed that an increase in periodontitis severity and lung functions followed a decreasing trend even after adjusting for smoking (in pack-years), which was statistically significant ( p < 0.001).

While HDL-C showed a decreasing trend, TC, LDL-C, TG, and DBP significantly raised across the quartiles of all lipid ratios (P-value < 0.001).

Total bilirubin, aspartate transaminase, and alanine transaminase in both groups showed a decreasing trend with time (time effect: F = 30.270, 17.340, and 13.380, respectively; all P < 0.001).

Overall, 500 students (48.4%) were at risk of clinical depression with a decreasing trend over academic years (59.3% in Year 1 to 35.5% in Year 6, p<0.001, see eTable 1 in the online supplemental material ).

In addition, a decreasing trend in age from northern to southern Italy was observed ( p = 0.001).

After matching, adalimumab still realizes a higher rate of clinical response than etanercept to some extent with equivalent safety in rheumatoid arthritis patients adalimumab efficacy etanercept rheumatoid arthritis safety In the matched cohort, the DAS28 ESR also showed a decreasing trend from W0 to W24 in the ADA group ( p < .001) and the ETN group ( p < .001).

A decreasing trend in the rate of malocclusion with age was observed, from 78.2% at age 3 to 63.2% at age 5 ( p = 0.001, Table 1 ).

A final change occurs in 2016 (p<0.001, Supremum Wald statistic=165.08), followed by a decreasing trend (beta coefficient: −0.66 (95% CI −0.88 to –0.44), p<0.001).

The data indicated a significant increasing trend in the prevalence of DM, from 8.3% (in 2009) to 9.7% (in 2019) (p=0.004), in contrast the prevalence of CVD among patients with DM showed a decreasing trend (from 33.9% to 20.4%; p<0.001).

Annual crime rates for the 2009–2016 period show a decreasing trend in both the general population (IRR = 0.981, 95% CI 0.978–0.983, P < 0.001) and in the FEP group (IRR = 0.019, 95% CI 0.012–0.028, P < 0.001); this pattern is more pronounced in the FEP group.

A decreasing trend was seen in the number of clients with low mental well-being across the three follow-up moments (p<0.001), with a significant difference between preintervention and 2 mo postintervention (p<0.001).

In the ROI H/L hypo-/hyperdense artifacts, as the VMI keV increased in each group of CI/VMI (50–150 keV) and CI/VMI + O-MAR (50–150 keV), the AI values showed a decreasing trend, and the differences were statistically significant (P<0.001).

pneumoniae strains, with a decreasing trend during the four semesters ( p -value < 0.001), which presented an 80% resistance rate to ampicillin/sulbactam and 73.33% to ciprofloxacin.

Considering the significance of the effect of time, pain intensity in the participants showed a decreasing trend in general up to 24 hours after the surgery (P < 0.001).

Kaplan–meier analysis of MAP and 28-day and 90-day mortality Kaplan–Meier analysis illustrated that compared with Quartile 1, the 28-day mortality in Quartiles 2, 3, and 4 showed a decreasing trend, and the difference between groups was significant (log-rank test = 36.82, p < 0.001, as displayed in the left panel of Figure 2 ).

However, the umbilical cord serum to maternal serum 25(OH)D ratio showed a decreasing trend with maternal serum levels ( P < .001).