“a favorable trend”

23 To the best of our knowledge, our study is the first to demonstrate a statistically significant improvement in outcomes associated with VCR versus CBCR coupled with a favorable trend in overall health care costs among patients participating in VCR.

31 Although the updated OS data presented at the 2025 ASCO annual meeting showed a favorable trend, statistical significance was not reached. 32 Moreover, another retrospective study reported that adjuvant nivolumab following neoadjuvant DCF chemotherapy could further improve both disease-free survival and OS in patients with locally advanced ESCC, with particularly pronounced benefits observed in those with ypStage III disease. 33 These studies suggest that patients who fail to achieve a complete pathological response may still benefit from intensified adjuvant therapy.

Conclusions Although a favorable trend is emerging, pooled data suggest that within the early treatment period (<12 weeks), BoNT-A may not be more effective than a placebo in reducing pPSS.

7.77%; HR 0.25; 0.07–0.85; p = 0.05) (although it is at the threshold, there is a favorable trend).

Moreover, there was a favorable trend for the use of Nas-air® concerning TST90, nocturnal SaO 2 and Nadir-SaO 2 as shown in Table 2.

Mean lean body mass showed a favorable trend of increment at week 6 (Δ 0.05 kg, 95% CI: −0.40, 0.49) and week 12 (Δ 0.16 kg, 95% CI: −0.33, 0.64) as compared to baseline in the intervention group but not in the control group which manifested decreasing lean body mass.

Although our study did not show any statistically significant benefit of propranolol therapy in the reduction of mortality, it showed a favorable trend by preventing worsening of HF symptoms and hospitalization.

wild type) was associated with longer OS, and EGFR exon 19 deletion showed a favorable trend.

Additionally, a favorable trend has been observed following the significant decline between 2019 and 2020 due to the COVID-19 pandemic ( OECD, 2023 ).

This result suggests that muscle mass trajectories differed between groups, with a favorable trend in the HIIT group, which showed a slight increase, compared with the LISS group, which exhibited a slight decrease.

Second, while the reduction in treatment-related SAEs showed a favorable trend, it did not reach statistical significance, and the estimate was based on a low absolute event rate (2 events in the short-course group vs. 10 in the long-course group); thus, the exact magnitude of this protective effect warrants cautious interpretation.

Four RCTs [ 40 , 47 , 48 , 53 ] were included in the meta-analysis, showing a favorable trend for dance but without statistical significance and with high heterogeneity (72%).

Of note, nevertheless, a favorable trend was observed in secondary and exploratory clinical outcome measures that became more marked in the open-label extension study with longer term follow-up, particularly with earlier tofersen initiation [ 34 ].

In contrast, manual rater thresholds exhibited a favorable trend for accuracy but not for specificity and sensitivity, likely influenced by poor inter-rater agreement. 4.4.2 Revised post hoc validation Consequently, we transitioned to a more focused validation method, as elaborated in the second stage of our process, providing a more targeted validation approach. indicating some variability in their assessments, yet demonstrating a generally consistent agreement with AIDAqc.

In patients with advanced cancer engaging in moderate exercise, a favorable trend was observed in inflammatory markers, with stabilization or slight reduction of IL-6 and CRP levels compared to sedentary controls (though results did not always reach statistical significance due to small sample sizes).

2 A), high TMEM71 expression was associated with significantly worse prognosis in multiple tumors, while it showed a favorable trend in some cancer types.

Among high SDI countries, the United States exhibits a favorable trend, with a net drift of −0.45% (95% CI: −0.69 to −0.21).

Many retrospective studies conducted among cancer patients upon treatment of local anesthetics including lidocaine and ropivacaine demonstrate a favorable trend of decrease in tumor metastasis and recurrence.

FeNO levels showed a favorable trend.

The lack of a statistically significant effect on all-cause mortality, despite a favorable trend, merits careful interpretation.

Although the number of patients in the crossover portion of the study was small, it showed a favorable trend of sustainable safety.

For BB, there was a favorable trend for the expression level of tight junction proteins, similar to the morphology results (Figure 3C‐D, G‐H ).

The results of treated groups showed a favorable trend in reducing tumor volume (more than 75% tumoral reduction).

Conclusion: Passive smoking was responsible for 1.4% of all deaths in Brazil during the period 2009-2021 and showed a favorable trend, with rates decreasing by half during the period.

(One woman was taking a statin at baseline but not at 3 and 6 years, and another woman was under statin treatment at the 3- and 6-year follow-up visits.) Except for glucose, which showed an increasing trend possibly reflecting an underlying propension of PWS, the mean values of the remaining laboratory markers showed a favorable trend, i.e., increase of HDL cholesterol, decrease in triglycerides, and decrease in systolic and diastolic blood pressure.