“a favorable trend”

In the subgroup analysis for OS, including propensity score‐adjustment and propensity score‐matching analysis, regorafenib was a favorable trend of OS in the younger patients, whereas TFTD was in the elderly patients.

For example, the KEYNOTE-061 trial, which evaluated pembrolizumab monotherapy versus paclitaxel in previously treated gastric cancer, failed to demonstrate a significant improvement in PFS or ORR, despite showing a favorable trend in OS among patients with high PD-L1 expression (CPS ≥10) ( 30 ).

Although GLP-1RA prescription was not significantly associated with a reduced risk, it demonstrated a favorable trend (HR, 0.65; 95% CI: 0.37–1.14).

Other interventions, such as TEII (SMD = 0.48) and TWDT (SMD = 0.37), also showed trends of being showed a favorable trend to the control group, but with wider confidence intervals and greater uncertainty.

Nevertheless, the CPET parameters began to show a favorable trend even at low doses [ 25 ].

In our study, receipt of radiotherapy was independently associated with better survival, and longer chemotherapy duration showed a favorable trend in exploratory analysis.

QLQ-C30 and QLQ-STO22 scores showed a favorable trend in trastuzumab plus chemotherapy compared to chemotherapy alone.

Overall, the IVTA group showed a favorable trend with fewer inflammatory recurrences and structural complications, thus suggesting a protective role of intraoperative IVTA against postoperative adverse events [ Table 6 ].

As shown in Table 4 , Aidi injection, Compound kushen injection, Delisheng injection, Huachansu injection, Javanica oil emulsion injection, Kangai injection, Kanglaite injection, Shenfu injection, Shengmai injection, Shenmai injection and Shenqifuzheng injection were 11 injections combined with NP, which demonstrated a favorable trend for relieving leukopenia compared with NP alone.

Iba et al demonstrated a favorable trend for AT supplement at a dosage of 3000 IU/day over 1500 IU/day for the treatment of sepsis-associated DIC. 13 In the treatment of Septic DIC, it may be necessary to adjust the optimal dose, taking into account not only the difference in source of infection, but also the severity of the patient’s illness and the status of coagulation-fibrinolytic disruption.

From the scant evidence that emerged about the treatment of cocaine use, it was not possible to highlight a favorable trend for dynamic or non-dynamic treatments for both outcome use and outcome participation.

LDL cholesterol presented a favorable trend (CI: −22.79 to 3.46), although not statistically significant.

In the third ΔTG tertile, fenofibrate treatment showed a favorable trend toward lower all-cause mortality among early-diagnosed patients, with a significant age-by-treatment interaction (P interaction = 0.012), whereas no benefit was observed among late-diagnosed patients.

While a favorable trend toward prolonged PFS was observed for the entire cohort with LR, the benefit reached statistical significance only in type II PVTT.

Further, results for ORR, PFS after first subsequent therapy, and OS in the Japanese subpopulation were largely consistent with those of the overall population and showed a favorable trend for amivantamab–chemotherapy versus chemotherapy.

Although intervention within 24 h showed a favorable trend in severe cases, it did not significantly improve outcomes compared with 24–72 h. status released display-pdf yes is-in-collection-domain yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Revised 2025 Apr 23; Received 2025 Mar 9; Accepted 2025 May 9; Issue date 2025 Aug. 1.

Conclusions: A favorable trend is observed with respect to the mean LOE as well as the number of level 2 studies and RCTs over time.

Establishing generalizable treatment algorithms for these patients remains challenging, but our data suggest a favorable trend toward the use of internal endomedullary fixation coated with PMMA.

13 ), it can be observed that from 1985 to 2020, the area of RSEI with sen > 0 accounted for 46.51% in the BTHSH region, suggesting that the eco-environment in this region demonstrated a favorable trend over the time series, and the area with sen < 0 accounted for 53.88%.

ET-calculated maximal pre-treatment k ep showed 100% sensitivity and specificity for predicting treatment response during the early phase of the therapy and reached a favorable trend to significant prognostic value post-therapy.

These findings suggest a favorable trend, but definitive cardiovascular benefit cannot be concluded until results from dedicated CVOTs, such as SURPASS-CVOT, become available.

Detecting the changes in the levels of urinary THP and PTX3 of each group, it was found that urinary PTX3 levels of CLAT and TLF groups were lower than pretreatment, whereas urinary THP levels in the CLAT group did not show a favorable trend post-treatment. urinary THP levels reflect kidney functioning mass and are of prognostic value for renal function.

The results suggest a continuing decline in the global burden of KC among both males and females, indicating a favorable trend (Fig. 5 ).

The current results suggested that MHO showed a favorable trend in the overall metabolic signature.

For the first time, we confirmed how G-Rh2 changed the biometabolic behavior of tumors by regulating PDK4, leading to a favorable trend towards normal apoptotic programming.