Barely Significant
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a trend toward significance

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a trend toward significanceP < 0.24.0× alpha
Univariable analysis showed that many variables had a trend toward significance ( P < 0.2) for association with the presence of individual, or groups of infectious agent(s) (Table 5 , Table 6 , Additional file 2 : Table S1, Additional file 3 : Table S2), and these were entered into the multivariable logistic regression analysis, together with variables having significant associations ( P ≤ 0.05).
a trend toward significancep < 0.24.0× alpha
A logistic regression model was conducted to evaluate clinical and sociodemographic variables that were either statistically significant in the univariate analysis ( p < 0.05) or demonstrated a trend toward significance ( p < 0.2), in order to identify potential risk factors associated with a reduction in PLT levels.
a trend toward significancep < 0.24.0× alpha
Variables that were statistically significant or had a trend toward significance ( p < 0.2) or were of a priori clinical significance were included in a multivariable analysis with forward stepwise ordinal logistic regression, to evaluate independent factors associated with medication non-adherence.
a trend toward significanceP =0.204.0× alpha
We sought further replication of the two chromosome 1 regions in an additional set of cases and controls from the United States ( Table 1 , Supplementary Table 2 ); rs7412746 clearly replicated (OR=0.86, P =0.0076, one-sided; meta-analysis of all three replication cohorts OR=0.89, P =1.5 × 10 −5 ), with rs3219090 showing a trend toward significance in the expected direction (OR=0.95, P =0.20, one-sided; meta-analysis of all three replication cohorts OR=0.91, P = 3.4 × 10 −3 ).
a trend toward significancep < 0.24.0× alpha
Any baseline patient demographics and surgery characteristics that showed significance or a trend toward significance ( p < 0.2) from univariate analysis were inputted into a binary regression analysis to determine which factors were most associated with the development of postoperative complications.