Metastasis status showed a trend toward significance (P = 0.126) Table 2 . 4 Discussion This study aimed to identify molecular prognostic biomarkers associated with neoadjuvant chemotherapy (NAC) response and the immune microenvironment in hormone receptor-positive (HR+)/HER2-negative breast cancer.
54.07, p=0.0439), and there was a trend toward significance in which ORR High DIPs had more publications than ORR Low DIPs (198.3 vs. 63.77, p=0.1267) ( Table 3 ).
3.3.4 Everyday Cognition 12 Scale ( ECog ‐12) Scores on the ECog‐12 decreased directionally with a trend toward significance in the GBP480 group ( p = 0.128, d = 0.650), and only directionally in the GBP240 group ( p = 0.270, d = 0.498) over the course of the 4‐week testing period, indicating a possible improvement in perceived cognitive functioning.
The intercept term showed a trend toward significance ( B = −0.96, SE = 0.63, P = 0.129).
For the interaction term between Prx4 and sex, there was a trend toward significance ( p = 0.13).
The Disc/Canal ROI ratio showed a trend toward significance (p = 0.13).
The results showed no significant between-group differences (RR, 1.61; 95% CI: 0.78–3.34) and the heterogeneity was not statistically significant, although with a trend toward significance (I 2 =42%; P=0.13).
Similarly, in the ANOVA, race was not a significant factor (p=0.341), while PALOP status showed a trend toward significance (p=0.13).
There was a trend toward significance for IDH status and KPS ≥ 70 at last follow-up ( p = 0.13 and 0.06, respectively).
Although a trend toward significance was noted for OS, this effect disappeared when we examined only the clear cell subtype (HR = 3.0; P = 0.14) ( Fig. 3 ).
These areas include the nucleus accumbens core (NAc-core, p = 0.03) and a trend toward significance in prelimbic cortex (PL, p = 0.14) (Fig. 4b ).
Nevertheless, Faecalibacterium showed a trend toward significance ( p = 0.14) for increased abundance in response to CAE treatment (V1 vs.
For TLR4 rs2149356, recessive model analysis indicated a trend toward significance for the GG genotype (52.7% in T2MH-DYS vs. 39.4% in T2MH; c 2 = 2.160,P = 0.142).
Consistent with this observation, plasma GIP levels following the oral glucose challenge were increased in transgenic mice compared to controls, reaching statistical significance at 10 min and showing a trend toward significance at 15 min ( p = 0.1431) ( Figure 6 J).
When stratified by sex, EV concentration showed a positive association with fast walking speed in both females ( r = 0.465, p = 0.031) and males ( r = 0.467, p = 0.039), and a trend toward significance in the chair test in males (r = 0.273, p = 0.144).
Model 3, focusing on age and NT-proBNP with an interaction term, reported a non-significant intercept of −28.6551 ( P = 0.1584, 95% CI: −68.4712 to 11.1609), with age showing a trend toward significance (estimate: 0.4224, P = 0.144, 95% CI: −0.1443 to 0.9892).
Induced nausea showed only a trend toward significance (AUC = 0.605, p = 0.145).
For CSA, the between-group difference in slope showed a trend toward significance (β = 0.02; 95% CI −0.02 to 0.06; p = 0.149), whereas no significant difference was detected for AP Z-scores (β = 0.01; 95% CI −0.02 to 0.05; p = 0.587).
As we observed a trend toward significance at the Cochran’s Q test ( p = 0.150), we decided to perform a post-hoc Bonferroni-corrected McNemar test, which resulted in: t0 vs t1, p = 0.063; t0 vs t2, p = 0.081; t1 vs t2, p = 0.246.
Moreover, a trend toward significance was found for physical inactivity and low education ( p < 0.150).
However, several variables showed a trend toward significance (p < 0.15) including the presence of multiple nodules (≥ 1), smoking status, portal vein thrombosis, BCLC stage, patient age, AFP and creatinine levels ( Tables 3A and 3B ).
Statistical significance was defined as P<0.05, with a trend toward significance defined as 0.05≤P<0.15.
Variables demonstrating a trend toward significance ( P ≤ 0.15) in the univariable analysis were included in the multivariable logistic regression model.
Moreover, the percentage of patients with detectable ARv7 in their liquid biopsies decreased from 57% to 25% and 15% and was null in patients classified as PD, SD, PR, and CR, respectively, thus mirroring the degree of response, although only a trend toward significance was observed ( p = 0.15).
The USscore itself showed a trend toward significance but did not reach statistical independence (OR per point increase =1.21, 95% CI: 0.94–1.58; P=0.15).