Barely Significant
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an important trend

481 sentences · 481 papers · 1,689 search hits before verification · confirmed specimen

Sighted at

p=0.066

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

Combined locoregional and systemic antitumor treatment in neoadjuvant therapy As both local therapies (vascular intervention, radiotherapy) and systemic antitumor therapies (molecular targeted drug treatment, ICI treatment) have their own therapeutic advantages and different antitumor mechanisms, attempting to combine therapeutic approaches to explore potential synergistic effects to improve patient survival is currently an important trend in the treatment of HCC (Table 3 ).
Nowadays, there are several therapeutic options for stage III BRAF mutated or wild-type melanoma in the adjuvant setting, but none of these have shown a statistically significant OS benefit (although dabrafenib/trametinib showed an important trend in favour of combination therapy over placebo), and all of these therapies have a toxicity profile that requires careful consideration [ 4 – 6 ].
The development of preclinical in vitro models reproducing the complexity of human joint diseases constitute an important trend in OA research, yet current models are still limited in their capacity to recapitulate the complex multicellular nature of human joints, hindering the development of an efficient therapy for OA ( Cope et al., 2019 ; Domínguez-Oliva et al., 2023 ; Malfait and Little, 2015 ; Perisin and Sund, 2018 ; Swearengen, 2018 ; Xie et al., 2018 ).