Barely Significant
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“an increasing trend”

63,972 sentences · 63,972 papers · 107,686 search hits before verification · confirmed specimen

Sighted at

p<0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

18 , 37 A randomized controlled trial in postmenopausal women also showed an increasing trend in the incidence of cardiovascular events with calcium supplementation. 38 Therefore, the specific dosage of dietary calcium intake and the health status of the study population may influence the association between dietary calcium intake and CVD or severe AAC.
Our previous findings have reported an increasing trend toward PD-1+CD4+ T cells in PB in AML. 8 Interestingly, a higher percentage of PD-1+IFN-γ+CD4+ T cells was found, indicating that PD-1/PD-L1 pathways may impact CD4+ T cell function through the tumor-infiltrating inflammatory cytokines IFN-γ. 33 Further comparative analysis of different patterns of PD-1 and Tim-3 on IFN-γ+ T cells found that PD-1 and Tim-3-mediated T cell exhaustion were principally involved in Th1 rather than Tc1, with Tim-3 mainly in the form of co-expression with PD-1.
Furthermore, pathway enrichment analysis indicated that alterations in amino acid metabolism, fatty acid metabolism, and Pan and CoA biosynthesis were associated with the development of DR 38 ; moreover, aspartate, glutamine, and Pan were the key factors related to the differential enrichment of these pathways, and Pan level in the vitreous cavity showed an increasing trend.
10 , 47 The incidence of proximal adenomas and cancers also shows an increasing trend with age. 48 Furthermore, compared with men, women appear to have a higher proportion of advanced adenoma and cancer in the proximal colon. 32 , 33 Overall, our assumptions likely entailed overestimation of the benefit of colonoscopy screening and hence provide an upper limit of what may be achieved with colonoscopy compared with sigmoidoscopy.