“an increasing trend”

Additionally, there was an increasing trend in Moran’s I value over time, peaking at 0.41 ( P < 0.01) in 2015–2022, suggesting a growing degree of spatial clustering in incidence rates (Table 1 ).

As shown in Table 1 , there was an increasing trend in BMI, SBP and DBP with the severity of disease, and the highest values were observed in the sPE group ( P < 0.01).

Year of HIV diagnosis was significantly associated with delayed ART initiation ( p <0.01), and there was an increasing trend of ART timely initiation since 2014 (trend χ 2 = 10.514, p <0.01, Figure 2 ).

In contrast, the variation of lip desquamation among females under the age of 38 showed an increasing trend ( r = 0.234, p < 0.01).

In HC and Mod/Sev, but not the MA subjects, stimulation of PBECs with EGF enhanced the chemotactic activity when compared to basal-CM (p = 0.021 in HC, 0.093 in MA and 0.010 in Mod/Sev asthma, Table S1); the EGF-CM activity was related to clinical asthma severity as shown by an increasing trend (linear contrast test p = 0.010) ( Figure 2A ).

coli , Enterobacter species and Serratia species had a steady isolation rate over the ten year period, while Klebsiella species showed an increasing trend in their isolation rate, from 22.6 to 50.9% (χ 2 = 29.1, P < 0.01) of the total Gram-negative bacterial group (excluding Salmonella species).

The THg and MeHg concentrations in the topsoil show an increasing trend with altitude ( r 2 = 0.68–0.71, p < 0.01 for both) ( Fig. 1 ).

In the case of RAB3A silencing, an overall mRNA decrease in all markers was observed in NG, as shown for synaptopodin (−3.93 FC, p < 0.01) and CD2AP (−2.18 FC, p < 0.05), whereas under glucose overload, an increasing trend was observed in all podocyte markers, significant for synaptopodin (3.15 FC, p < 0.01) and WT-1 (4.75 FC, p < 0.05) ( Figure 2 A).

In the GG, the scores for happiness, appetite, hygiene, general health and owner pain showed an increasing trend starting from D2 ( P < 0.01); the mobility score decreased at D1 ( P < 0.01), followed by an increase at D3 ( P < 0.01), and the vet pain score exhibited a decreasing trend at D1 ( P < 0.01), followed by an increase starting from D2 ( P < 0.01).

An increasing trend was observed in men (26.0% in 2018, 26.7% in 2019, 28.8% in 2020 and 32.1% in 2021; p<0.01), while the prevalence was stable in women (7.3%, 7.7%, 7.4% and 8.3%; p=0.16).

Lake area of Hulun (13.98 km 2 /year, p < 0.01) and Nanhaizi (0.002 km 2 /year, p < 0.01) exhibited an increasing trend, while Dalinor (−1.01 km 2 /year, p < 0.01), Chagannaoer (−0.18 km 2 /year, p < 0.01), Daihai, and Juyan (−0.19 km 2 /year, p < 0.01) lakes decreased.

Most blood parameters showed no significant breed differences ( p > 0.05), but heat shock protein 70, a key regulator of thermal adaptation, exhibited an increasing trend in both breeds ( p < 0.01), appearing earlier than other physiological indicators of heat stress.

TIAC changed during RLT, showing an increasing trend from cycle I to cycle IV in the kidney (mean difference = − 0.21 ± 0.39 h, p < 0.01) and a decreasing one in the liver (mean difference = 5.1 ± 14.16 h, p < 0.01) and in the WB (mean difference = 9.37 ± 15.19 h, p < 0.01), but remained constant in spleen (mean difference = − 0.18 ± 0.96 h, p = 0.12) and red marrow (mean difference = − 0.10 ± 0.05 h, p = 0.64).

Compared with mice in the control group, mice in the model group showed an increasing trend in the Penh ratio when stimulated with 0, 6.25, 12.5, 25, and 50 mg/mL acetylcholine ( P < 0.01), thereby corroborating the modelling of AA mice, the GMK group had lower Penh values than the model group ( P < 0.001).

In contrast, the H7N7 infected control animals showed an increasing trend of weight loss that was significant compared to the vaccinated H7N7 infected mice on day 7 ( p = 0.01) and day 8 ( p = 0.0003) post H7N7 infection ( Figure 1E ).

The abundance of dsyB showed an increasing trend from north to south, and was negatively correlated with latitude ( p < 0.01, Spearman correlation tests, Supplementary Table 7 ).

Smoking history, measured with packyears of smoking, also exhibited an increasing trend with increasing frequency of breathing pauses and night awakenings ( p = 0.011 and p < 0.001, respectively) ( Table 4 ). 3.5.

Specifically, there was an increasing trend in lung cancer risk across the DMFT tertiles (linear trend, p = 0.011; global trend, p = 0.011).

By contrast, our study demonstrated an increasing trend in the rate of contact lens-related microbial keratitis in our hospital over the 10-year study period ( P = 0 .011).

Male flies on CDFs show an increasing trend in body weight compared to males aged on RF (Friedman test; n = 4, p≤0.0116 for all; see Table S2D for details).

The results showed that CAC scores remained stable in the OL-HDF group, whereas the HDx group showed an increasing trend ( p = 0.012).

Bladder cancer The crude and age-standardized mortality rates for bladder cancer were 0.8 and 0.5 in 2013, respectively, rising to 1.8 and 1.4 per 100,000 people in 2021, indicating an increasing trend ( P = 0.012).

In contrast, an increasing trend was observed for lopinavir (from 25.0% to 28.1%, p = .012), fosamprenavir (from 0% to 7.0%, p < .0001), atazanavir (from 2.3% to 23.8%, p < .0001), darunavir (from 0% to 16.3%, p < .0001), and tipranavir (from 0.6% to 1.6%, p < .0001).

Interestingly, activated eTreg (CD4 + CD25 hi CD127 low CD45RO + CCR4 + HLA-DR + ) showed an increasing trend from 3 to 7 years, were more marked in the 5–7-year range (median 22.8% at 1-3 years vs 34.4% at 5-7 years; p = 0.012), and the frequency decreased thereafter ( Supplementary Figure 4G ).

2), with an increasing trend indicated by linear ( P = 0.012; Table 3 ) and joinpoint (AAPC 5.229%; 95% CI: 0.9–8.455; P = 0.018; Table 4 ) regression.