In contrast, an increasing trend was observed for lopinavir (from 25.0% to 28.1%, p = .012), fosamprenavir (from 0% to 7.0%, p < .0001), atazanavir (from 2.3% to 23.8%, p < .0001), darunavir (from 0% to 16.3%, p < .0001), and tipranavir (from 0.6% to 1.6%, p < .0001).
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1, the min longitude of JE emerging townships displayed a decreasing trend of 0.007 per month ( P = 0.034), while the max latitude of JE emerging townships exhibited an increasing trend of 0.009 per month ( P = 0.012).
For increased oxygen demand (≥20% increase in FiO 2 or change to advanced respiratory support): the incidence of one, two, and three doses was 31.1% (5/16), 50.0% (16/32), and 87.5% (7/8), in that order, with the Cochran–Armitage trend test showing an increasing trend (P = 0.013).
We identified seasonal joinpoint trends in Shigella outbreak frequency, revealing an increasing trend until October, with an APC of 3.03% (95% CI: 0.76 to 7.60, p = 0.013), and a decreasing trend thereafter, with an APC of −25.79% (95% CI: −37.31 to −9.21, p < 0.05) ( Supplementary Figure S4 ).
Although there were no significant differences in SMI gain between the groups in either sex (all p > 0.05), a significant difference in TMI gain was observed among women, with the BBS improvement group showing an increasing trend compared with the no BBS improvement group (0.06 vs. −0.15 kg/m 2 , p = 0.013).
We observed an increasing trend in diversity from the HC to CRC ( p = 0.013, compared to HC) ( Figure 2 a).
Quantifying the number of these EDC4-laden astrocytes and normalizing to the number of GFAP + cell bodies per high powered field, we observed an increasing trend in the proportion of EDC4-laden astrocytes in the chronic active lesion borders compared to in NAWM ( Figure 4D ; p = 0.0136).
In the wavefront- optimized group, root mean square of total higher-order aberration ( P = 0.091), coma ( P = 0.115), and trefoil ( P = 0.459) all showed an increasing trend 3 months postoperatively, with a statistically significant two-fold increase in spherical aberration ( P = 0.014, Figure 2 ).
Both BMD and T-scores at the lumbar spine exhibited an increasing trend compared with the “<1 year” group to the “>5 years” group ( P = .014, P < .001, respectively).
Compared with the baseline, the total HIV DNA exhibited an increasing trend at week 4 ( P = 0.014), but subsequently demonstrated a declining trajectory at week 8, ultimately returning to baseline levels by week 12 and week 24 (Fig. 3a, b , Supplementary Figs. 2b , 3 ).
EV Tg 330 kDa normalized to CD63 showed an increasing trend according to a differentiation score of the lesion (calculated according to histology and aggressiveness) ( Supplementary Figure S3 ; Spearman’s rho = 0.430, p = 0.014).
Moderate hypoxaemia (51%–80%) showed an increasing trend as the time since recovery from fever decreased, with the highest incidence in the 0–2 weeks group at 2.8% and the lowest in the 7–8 weeks group at 0.7% (p=0.014).
Intraplaque injections were the most frequent therapy (7.2%) and showed an increasing trend ( p = 0.014).
The mean of oxytocin plasma levels showed an increasing trend in the scary video game-play (P=0.01474) ( Figure 3 ).
An increasing trend in the efflux of Fe 2+ was however noted with increasing duration of hypoxia (r = 0.59, p = 0.015, Fig. 3F ), but no significant differences between treatments were observed (p = 0.088, Table S2 ).
Regarding the choice of anti-VEGF drugs, bevacizumab was chosen more frequently than the other two drugs ( P < 0.01), and there was an increasing trend ( P = 0.015) for aflibercept and a surge in 2021.
After the intervention, there was an increasing trend in glove purchase figures (Table 3 ), associated with a significant increase in compliance with the glove use procedure from 76 to 89% ( P = 0.015).
Calanoid and cyclopoid copepods demonstrated an increasing trend in density as average current strength also increased ( p = 0.015, r 2 = 0.81).
An increasing trend of broad-spectrum antibiotic consumption was observed after the onset of the pandemic ( β 3 = 0.021; p = 0.015).
In the yolk, there was an increasing trend ( P = 0.015), with a decrease on d 18 ( P < 0.001).
1 ), with an increasing trend of 4% per year ( p = 0.015).
From a developmental perspective, the abundances of Arthropoda exhibited an increasing trend with host maturation ( W = 8.34, p = 0.016), while Cercozoa and Ciliophora gradually declined ( W = 7.46, p = 0.024 and W = 8.65, p = 0.031, respectively).
After removing the interval after the COVID-19 pandemic onset (evaluating from 2014 to 2019) in outpatient dental care, it was observed that there was an increasing trend in the incidence of outpatient dental procedures carried out by special care dentistry specialists in the southeastern region ( p -value = 0.016, R 2 = 0.846, APC (%) = 23.0%, 95% CI = 13.5–36.8%) and central–western region ( p -value = 0.029, R 2 = 0.833, APC (%) = 12.2%, 95% CI = 4.2–16.9%).
An increasing trend was detected for hemoglobin levels (P = 0.016).
Considering all isolates, amoxicillin non-susceptibility showed an increasing trend (R 2 = 0.528; p = 0.017).