When TSP1 KO MHEC (in the absence of TSP1) were challenged with the parasite, we observed a significant decrease in the levels of p-GSK-3β (Ser9) at 1 h (0.57±0.12; P< 0.01) followed by an increasing trend from 2- to 6 h that was maximum at 2 h (2.99±0.24; P< 0.001) compared with control ( Fig 2B ).
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Female sex showed a decreasing trend (36.45% to 35.09%, p=0.001) of admissions while an increasing trend was noted in males (41.85% to 46.64%, p=0.001) and ethnicities except for Native Americans.
Imipenem-resistant UPEC isolates showed an increasing trend ( P = 0.001), while decreasing resistance trends were observed for ampicillin ( P = 0.013), ampicillin/sulbactam ( P = 0.013), ceftriaxone ( P < 0.001), gentamicin ( P = 0.001), tobramycin ( P = 0.011), trimethoprim/sulfamethoxazole ( P = 0.028) ( Table 1 ).
In the period before PrEP enrollment, there was an increasing trend in quarterly C trachomatis or N gonorrhoea positivity (RR increase, 1.08 per quarter [or an 8% increase per quarter]; 95% CI, 1.05-1.11 per quarter; P < .001); however, no trend was observed after starting PrEP (RR increase, 1.01 per quarter; 95% CI, 0.99-1.02 per quarter; P = .29).
The ReHo values of the caudate showed an increasing trend from ReHo controls (0.81±0.06) to ReHo non-HE (0.96±0.08) to ReHo MHE (1.03±0.17) ( F = 25.317, P <0.001).
There was an increasing trend in whether antibiotics had ever been prescribed with increasing deprivation score (Table 2 ; p < 0.001) which was not moderated by patient group ( p = 0.3).
A significant reduction over time was found for the contributions of HI and PET ( p < 0.001 and p < 0.05, respectively), but the HD and RC n contributions showed an increasing trend ( p < 0.001 and p = 0.12, respectively).
The results suggest an increasing trend of mass shooting incidences over time (p < 0.001).
1 A], but not significant in subgroups; proportion of 30-day ART initiation showed an increase trend of 1.0% per month before treat-all (IRR = 1.010, 95% CI : 1.001–1.018; P = 0.030), and after treat-all showed an increasing trend of 0.8% per month (IRR = 1.008, 95% CI : 1.006–1.010; P < 0.001); by the end of 2019 (December 2019), proportion of 30-day ART initiation was not significantly different from the expected level (IRR = 1.044, 95% CI : 0.681–1.600; P = 0.844).
There was an increasing trend in solid tumors (80.6% vs. 70.7%, p < 0.001).
However, when the level of α-HBDH increased, the correlation between α-HBDH and in-hospital mortality showed an increasing trend ( P < 0.001).
Inflammatory markers measurement As seen in Figure 6 , the production of IL-6 and TNF-α in ethanol treatment group had an increasing trend as compared with the control group in the liver ( P< 0.001 and P< 0.05, respectively).
An increasing trend of risk of all-cause and heart disease mortality from group 1 to group 4 was observed ( P < 0.001 for trend; detailed statistical results are shown in Supplementary Table S1 ).
An increasing trend was observed in the mean levels of serum ALT and GGT across the SUA quartile groups (p < 0.001 and p < 0.01, respectively).
D3 smokers showed an increasing trend between 2000 and 2010, following adjustment (GLF, P < 0.001; HSE, P = 0.04) with no significant trend found for D1 and D2.
It shows an increasing trend on IgG positive rates(χ2 = 49.0, P < 0.001).
Summer averaged concentrations in MTZ1 show an increasing trend over 1995–2015 (slope = 2 mg L −1 yr −1 , p < 0.001, R 2 = 0.566, Fig. 2C ).
In addition, the protein expression of MMP2 and MMP9 in the MCM and MTM also showed an increasing trend after IκBα-siRNA intracameral injection by IF (MMP2 in the MCM, p = 0.0011; MMP9 in the MCM, p = 0.0013; MMP2 in the MTM, p = 0.0040; MMP9 in the MTM, p = 0.0106) ( Figures 5 E, 5F, 5H and 5I).
We observed a significant difference in ANC utilization, with most women not receiving ANC, showing an increasing trend overtime (χ 2 = 13.65, df = 2, p = 0.0011).
Linear regression analysis of annual incidence highlighted an increasing trend in invasive CM rates across the country, with an annual increase of 0.59 cases per 100,000 individuals ( R 2 = 0.90; p = 0.0011) ( Figure 1 ).
As for the Non-Diab group, we found an increasing trend for non-Hodgkin lymphoma [APC: 3.23% (1.25–5.15%), p = 0.0011] and thyroid [APC: 3.07% (0.67–5.38%), p = 0.0112] cancers, and a decreasing trend for gallbladder [APC: −6.04% (−8.98–−3.20%), p < 0.0001], stomach [APC: −5.25% (−7.12–−3.43%), p < 0.0001], colorectal [APC: −1.17% (−1.99–−0.37%), p = 0.
At 913 s −1 , the MPA relevant flow dynamic condition, an increasing trend of tPA‐induced clot digestion rate (19% increase of Slope FluFF , p = 0.0013) was observed when pulsatile pressure amplitude increased from 4 to 40 mmHg or dampener size decreased from 60 to 6 cc (Figure 6a ).
Functional richness (FRic) showed an increasing trend across all bays in both spring and fall (logFRic ~ Year, p = .0018 and p < .0001 for spring and fall, respectively, Figure 2a ).
The downstream mRNA C1 regulated by miR-4685-3p showed an increasing trend in the CHD_KDBS group, which was higher than that in the Normal group ( P = 0.0019).
There was an increasing trend in obese GP hospitalizations, from 2286 in 2007 to 47,265 in 2017 (P=0.0019), and in the proportion of obese GP hospitalizations, from 6.16% in 2007 to 17.96% in 2017 (P<0.001).