“approaching significance”

0.832, p = 0.015), IDI (−2.59%, p = 0.003), and NRI (approaching significance, p = 0.160).

The paired-samples t -tests, α = 0.01, with a mean difference of 0.565, 99% CI [0.017, 1.112], p = 0.008 for the ANN, 0.437, 99% CI [0.151, 0.722], p = 0.0003 for the LDA, 0.488, 99% CI [0.083, 0.892], p = 0.003 for the LIN-SVM, and 0.372, 99% CI [−0.111, 0.857], p = 0.040 for the RBF-SVM, all revealed significant differences or approached significance between the two approaches without any correction for multiple comparisons (noting that only the LDA result remained significant, p = 0.0012, after Bonferroni correction, with the ANN, p = 0.032, and the LIN-SVM, p = 0.012, approaching significance; the RBF-SVM, p = 0.16, would be considered not significant).

It is possible the small sample size made it difficult to detect significant effects (e.g., the model predicting the total performance score from total TA hours was significant before adjustment, approaching significance after adjustment, FDR p = .16).

Mannose binding protein ( Q98TA4 ) was also increased in abundance and approaching significance ( p = 0.16) on Day 35 in GHP1 samples ( Supplementary Table S1 ).

95% confidence intervals are wide, reflecting this is not robust, but within subject differences over time were approaching significance in a univariate model of emotional support ( p = 0.165) (and not over social support ( p = 0.381)). 3.7.

In complete or partial responders (CR/PR), lymph node tissue demonstrated the strongest negative correlation ( r =-1.00, p = 0.0833), approaching significance; the “other” tissue category also showed moderate negative correlation ( r =-0.657, p = 0.175).

Case-control studies found a trend towards association of PD and CAD approaching significance (OR = 1.47, 95% CI = 0.84–2.56, p = 0.18; Fig. 2 ).

Significant associations were observed regarding the intake of individual carotenoids, including β-carotene (τ = 0.39, p = 0.0003), zeaxanthin, and lutein ( ρ = 0.58, p = 0.0001), apart from lycopene (τ = −0.09, p = 0.40) and α-carotene, which was approaching significance (τ = 0.14, p = 0.19).

We found a positive correlation approaching significance between sLF and MRT score (Pearson's = 0.342; p = 0.194; Figs. 2 and 3 ).

Variables at or approaching significance on univariate analysis (p<0.2) and clinically relevant variables were entered in the models.

Variables approaching significance differences ( p < 0.2) between those readmitted and not readmitted within 30 days were included in a binary logistic regression analysis using a backwards Wald selection method to determine factors associated with being readmitted within 30 days of the index admission. 3.

In accordance with Hosmer and Lemeshow, we entered the variables whose p values were statistically significant or approaching significance (p < .20) in the bivariate analysis in the logistic regressions [ 22 ].

Variables at or approaching significance on univariate analysis (p < 0.2) were entered in the models.

Every univariate parameter reaching or approaching significance (p < 0.2) was then tested in a Cox multivariate model using the conditional backward method.

Interactions between Aboriginality and remoteness, stage, age and comorbidity score, respectively were tested and included in the final model if approaching significance ( p < 0.2).

Risk factors approaching significance ( P < 0.2) in bivariate analysis were included in a multivariable logistic regression using the backward elimination procedure.

Genetic variants identified as approaching significance (using the standard p<0.20 [ 17 ]) were characterized as having the potential to predict weight change, and were included with demographic characteristics in subsequent regression modelling for aim 2.

Risk factors approaching significance ( P < 0.2) in bivariate analysis were retained for multivariable logistic regression using a forward stepwise procedure.

Variables at or approaching significance at univariable analysis (cutoff set at P < .20) were included in multivariable analysis.

While it appears that DAT is increased at baseline relative to other groups, this difference was not statistically significant, approaching significance most closely at 2 min ( p = 0.231, ANOVA).

The initial multivariable model included all variables approaching significance ( p < 0.25) in the bivariate model, plus all plausible two-way interactions provisionally detected by changes in odds ratios between the bivariate analysis and a full main-effects model.

Variables that were statistically significant or approaching significance ( p -value < 0.30) were utilized to construct a multivariable logistic regression model.

These differences were not statistically significant, although were approaching significance in the high temperature (standard vs low: P=0.32, standard vs high: P=0.15).

Paired sample t-tests between sample and choice DR suggest intact memory in Wt males and Wt females at 5 min (Wt males, 5 min: t 10 = −3.253, p = 0.009; Wt males, 3 h: t 10 = −2.787, p = 0.019; Wt females, 5 min: t 7 = −6.195, p < 0.001), but impaired memory in Wt females at 3 h (although approaching statistical significance; t 7 = 2.071, p = 0.054), and 5xFAD mice in all conditions, as they failed to discriminate between the novel and sample objects (5xFAD males, 5 min: t 9 = −2.062, p = 0.069 (although approaching significance); 5xFAD males, 3 h: t 9 = 1.009, p = 0.339; 5xFAD females, 5 min: t 10 = −0.407, p = 0.692; 5xFAD females, 3 h: t 10 = 0.870, p = 0.405). 3xTG mice, however, were impaired in a delay-dependent manner (2 × 2 × 2 split-plot ANOVA: genotype (F 1,36 = 26.260, p < 0.001), delay (F 1,36 = 19.172, p < 0.001), and genotype x delay (F 1,36 = 21.012, p < 0.001); Fig. 1g ).

The rate of blastocyst development between CRISPR injected embryos and non-injected controls was also not significantly different at day 5 or 6, but was approaching significance by day 7 of embryo culture ( p = 0.35, 0.08, 0.06, n = 566, 863, 859, 3 replicates, respectively).