Further intersection of these differential pathways with the total pathway intersection set obtained for the TCGA vs ANTE/GTEX comparison returned a list of non-random (p = 0.016) common 52 upregulated pathways and borderline significance (p = 0.055) list of six downregulated pathways ( Table S7 ; Fig. 5 C,D).
Our previous meta-analysis [ 13 ] found neuropathy to be a significant risk factor for ulceration; however, in the present study it had borderline significance ( p = 0.055).
On multivariate analysis adjusting for relevant factors, low GNRI remained an independent predictor of both worse PFS (HR 2.84, 95% CI 1.34–6.02, p = 0.006) and OS (HR 3.09, 95% CI 1.40–6.82, p = 0.005), whereas IPI ≥ 3 independently predicted inferior PFS (HR 2.11, 95% CI 1.03–4.32, p = 0.042) but showed only borderline significance for OS (HR 2.09, 95% CI 0.99–4.41, p = 0.055).
In contrast and interestingly, AA had a lower C-reactive protein (CRP) than CA with a borderline significance (P = 0.055).
Kaplan–Meier analysis ( Figure 2 ) revealed that the high leukocyte count group showed significant association with CAS progression (log-rank p = 0.01), while LDL-C groups demonstrated borderline significance (log-rank p = 0.055).
Borderline significance, such as P = .055 were regarded as insignificant.
As β-blockers were predominant in that group of medications (27/35), we performed additional post hoc analysis that used β-blockers only and it produced the borderline significance in logistic regression model ( P =0.055), suggesting that either the sample was too small to provide definite evidence or that some other drugs also contributed to the overall finding.
Multivariate analysis within the ELN risk groups confirmed t-AML to be no independent risk factor for OS, RR and NRM, although there was borderline significance for inferior OS of t-AML patients within the intermediate I/II risk group ( p = 0.055, Supplementary Fig. 1 ).
LOC285194 (also known as TUSC7) was down-modulated, but exhibited only borderline significance (p < 0.055).
In the development cohort, the Hosmer–Lemeshow test yielded a non-significant P -value of 0.299, while the temporal validation cohort showed borderline significance ( P = 0.055), indicating acceptable model calibration.
However, after adjusting for traditional risk factors, the association showed borderline significance ( P = 0.055).
In adult females, for each one-unit increase in systolic blood pressure, the odds ratio of obesity increased 1.026 times (95% CI, 1.010–1.043, p = 0.002), but diastolic blood pressure had an odds ratio of 1.021 for obesity, indicating borderline significance but not a definitive effect ( p = 0.055).
Low expression of PanCK showed borderline significance (p=.055).
44.0%, p< 0.05), and higher rates of affected surgical margins, with borderline significance (22.6% vs. 17.8%, p= 0.055).
There was borderline significance between SGA at baseline and severity of infection ( r = −0.337, p = 0.055).
The borderline significance of anemia in our multivariable model ( p = 0.055) suggests that ID is not merely a precursor to anemia but an independent metabolic failure that occurs even before hemoglobin levels drop.
The 6-year cumulative incidence of late grade 2 or higher GU toxicities was higher in the ≥ 66 Gy group than in the < 66 Gy group with borderline significance (Fig. 5 a, 14% [95% CI, 9.7–20] vs. 3.2% [95% CI, 0.6–10], p = 0.055).
The younger age group (3–14 years) was 2.17 times more at risk of developing VL than the older age group of >45 years (RR = 2.17; 95% CI = 1.39–3.37, p = 0.001); but the age group of 15–45 years showed borderline significance compared to the older age group of >45 years (RR = 1.55; 95% CI = 0.99–2.41, p = 0.055).
Although the association of the rs55903358 C allele with diminished TC-lowering efficacy was NS, it approached borderline significance ( P = 0.055; Table 3 and Fig. 4 b).
Mortality was more prevalent in preterm infants with borderline significance (0% vs. 66.7%, p = 0.055).
There was a low but borderline significance (Mann Whitney test, p = 0.055) of the viral genome load in the anti-EBOV IgG treated guinea pigs compared to the untreated animals, with a 3-log median value decrease obtained on day 3 post-infection (i.e., as assessed in 10 animals, in the serum harvested before the second injection of anti-EBOV IgGs in group 4).
Univariate Cox regression analyses indicated that LN status and ADC75 of the tumor were significantly associated with tumor recurrence ( p = 0.024 and p = 0.012; hazard ratio [HR], 4.543 and 1.099, respectively), whereas MTD, mADC, and ADC50 showed borderline significance ( p = 0.055, p = 0.051 and p = 0.095, respectively).
4.9%, p = 0.049), and borderline significance observed in the left femoral head (10.6% vs. 5.1%, p = 0.055) and sacrum (63.5% vs. 52.1%, p = 0.066).
The combination of IL-6 and CRP i had a higher area under the curve than PCT, but with borderline significance ( p = 0.055).
Concurrent use of antiplatelets was a possible protective factor for major amputation with borderline significance (OR, 0.37; 95% CI, 0.13–1.02; P = 0.055).