Barely Significant
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“borderline significant”

11,410 sentences · 11,410 papers · 14,072 search hits before verification · confirmed specimen

Sighted at

p=0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

For prediabetes reversal, the baseline static values of AIP and its obesity-associated indices showed no significant association with outcomes; in contrast, their dynamic control patterns demonstrated significant or borderline significant associations.
Recently, a cross-sectional analysis of 205 rural women in Sichuan, China found a borderline significant positive association between PM 2.5 exposure and blood pressure among those 50 years or older after adjusting for sodium intake and other CVD risk factors (e.g., second-hand tobacco smoke exposure and alcohol intake) but did not explore other dietary factors [ 11 ].
20 In the MrOS-US cohort ( n = 1817, mean age 74 yr, mean follow-up 4.6 yr, 157 hip fractures), FT4 was not associated with fracture risk, whereas there was a borderline significant association between TSH (per SD decrease) and increased risk of hip fractures in men with normal TSH (0.55–4.78 mIU/L). 21 We did not detect any association between thyroid hormone levels and hip fracture risk in a previous analysis of MrOS-Sweden with shorter follow-up time (median follow-up 9.8 yr, 127 hip fractures). 22 In contrast, in the present study with longer follow-up and more incident hip fractures, we found an association between higher FT4 and increased hip fracture risk.
When further adjusting for maternal vitamin D, B12 and folate status, the association with ethnicity disappeared ( Table 4 , Model 2), the association with GDM was somewhat attenuated and only borderline significant while the association with LDL-cholesterol remained significant.
These results highlight methodological challenges in detecting weak causal effects (e.g., OR≈1 for AD) and underscore the robustness of high-powered associations (ALS/MS/PD), emphasizing the necessity of integrating power assessments when interpreting MR outcomes, particularly for borderline significant findings or studies with constrained sample sizes.