did not quite reach significanceP = 0.06
Compared to the control group, the total fraction of enhancing brain voxels was significantly increased during the full course of disease as well as in the terminal phase (6 to 48 hours, Two-way ANOVA, P = 0.0019 and 36 to 48 hours, P = 0.019), but did not quite reach significance during the developing phase (6 to 30 hours, P = 0.06).