Barely Significant
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extremely significant

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extremely significantP<0.010.2× alphaqualified
As seen in Table I , there were no significant differences in the expression levels of hsa_circRNA_103135, hsa_circRNA_103137 and hsa_circRNA_101116 (P>0.05), but there were extremely significant differences in the expression levels of hsa_circRNA_103127, hsa_circRNA_103112 and hsa_circRNA_104907 (P<0.01) between six children with DS and six children without DS.
extremely significantP <0.010.2× alphaqualified
As shown in Figure 4 , compared with the controls which were MCF-7/ADR cells with no inhibitor pretreatment, the cellular uptake efficiency of PAMAM-NH 2 in MCF-7/ADR cells increased to an extremely significant degree with the addition of VRP ( P <0.01) and to a significant degree with the addition of FTC ( P <0.05), but the addition of MK571 effected no change in such efficiency.
extremely significantp value < 0.010.2× alphaqualified
Statistical analysis of the relative mRNA expression level between transcriptomic data and qPCR data was performed using Student’s t-test with SPSS 26.0 (v26) software, and the differences were considered significant when the p value < 0.05 (*) and extremely significant when the p value < 0.01 (**). 5.