The presence of PTEN gene loss in the absence of ERG/ETV1 gene rearrangements identified a patient population (6%) with poorer cancer-specific survival that was highly significant (HR=4.87, P <0.001 in multivariate analysis, 13.7% survival at 11 years) when compared with the ‘good prognosis’ group.
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Furthermore, there was a highly significant increase in CRP and mGPS between patients who had lost ⩾10% weight compared with those who had not (median CRP 16.5 vs 6.0 mg l –1 ; median mGPS 1 vs 0; P =0.001 for both tests).
Convergent and discriminant validity yielded both highly significant results (r = .79, p < .001, resp. r = .38, p < .001).
There was a highly significant correlation between BMI and fat mass, measured by DEXA (r = 0.85; p<0.001).
We found a significant effect of age : w AlbB interaction ( F = 4.55, P = 0.037), a significant effect of population ( F = 3.58, P = 0.034) and a highly significant effect of w AlbB ( P <0.001), while all other interactions or main effects were non significant ( P >0.05).
Highly significant ( P < 0.001) correlations between treatments were observed for the length traits leaf length, plant height, root length and both ratio traits.
Urgency of operation (emergency) had a highly significant suppressive effect on PONV risk in the crude bivariate logistic regression model at the 5% level (odds ratio 0.176; CI, 0.072-0.43; P < 0.001) (Table 2 .).
With respect to the valence ANOVA there was, unsurprisingly a highly significant effect [ F (1, 60) = 178.87, p < 0.001].
Furthermore, highly significant reductions of both the E058Δ iucA Δ iutA and E058Δ iucC Δ iutA double mutants were observed in all five tested tissues ( P <0.001).
The differences in mean weights between high-fat- and standard-fed mice were highly significant ( P < 0.001) from age 9 wk onward (6 wk on diets).
However, the analysis did show a highly significant (p<0.001) negative correlation between SerpinB2 and T-bet mRNA levels ( Fig. 3B ).
A significant increase in appetite VAS score ( P = 0.04) and a highly significant reduction in CGI-S score was observed ( P < 0.001).
Excretion of cortisol in HFA group showed no significant alteration from the control group (Phase I: 43.8 ± 4.43 vs 46.5 ± 6.60, 95% CI 43.16-49.84 P = 0.179; Phase II: 21.1 ± 2.87 vs 22.5 ± 2.52, 95% CI 21.22-23.78 P = 0.352; Phase III: 9.9 ± 1.20 vs 9.0 ± 0.97, 95% CI 8.51-9.49 P = 0.177, post-hoc Bonferroni test) but showed a highly significant alteration at the phases I (74.3 ± 8.62 vs 46.5 ± 6.60, P < 0.001), II (62 ± 7.68 vs 22.5 ± 2.52, P < 0.001), and III (40 ± 5.73 vs 9 ± 0.97, P < 0.001) when compared to LFA group.
The multiple R for the full model was highly significant (R = .90, F (3,15) = 20.27, p < .001), accounting for 80% of the variance in 2-back performance decline.
In contrast, I–V relations in the presence of 1.8 mM Ca 2+ revealed a strong inward rectification with a highly significant larger R iCa of 1.68 ± 0.09 ( p < 0.001; Figure 3 B).
The Kaiser–Meyer–Olkin measure of sampling adequacy was 0.73, which is above the recommended value of 0.60, and the Bartlett’s test of sphericity was found to be highly significant (Χ 2 = 1.830, p < 0.001).
All tests showed that MWs affected formation of 53BP1 foci at highly significant levels ( p < 0.001).
Chi squared for trend was highly significant (p<0.001).
As expected, FVB/N KLF2−/− and Tie2-cre KLF2−/− showed highly significant (p<0.001) decreases in the number of mesenchymal cells in the endocardial cushion tissue associated with the AV canal, compared to controls.
We found highly significant increases of pABG (p≤0.001, Figure 4C ) and apABG concentrations in spot urine (p≤0.001, Figure 4D ) from baseline with habitual folate intake to week 6 and week 12 of supplementation in subjects supplementing 400 μg folic acid per day in addition.
As for AURKA, the differences in protein expression levels of BUB1B in the different histological subtypes of TGCTs were highly significant ( P <0.001).
There was a highly significant group effect on all three components [ F (3,128) > 32, P < 0.001)].
The DFA was highly significant (Wilks’ lambda <0.001; Chi-square 65 = 392.0; P <0.001).
For all of the laboratory-raised birds a DFA based on morphological variables was highly significant (Wilk's λ = 0.12, P<0.001) and correctly identified 100% of the individuals in a post-hoc classification based on a prior expectation of 50% correct classification by chance alone.
When the nested design was conditioned on the eight covariates, household was still highly significant ( P = 0.001) and explained >36%.