“highly significant”

Associations were classified as highly suggestive (Class II) if they involved more than 1000 participants, exhibited highly significant summary associations (p value <10 − 6 by random-effects) and had the largest study showing a nominally significant result (p<0.05).

The other primary variables, that is, height, age, age 2 , elevation and sex, were all highly significant ( P < 10 −6 in all cases).

The differences between MS and control findings was highly significant (p > 0.000001).

Significant differences were observed between the SIDS and non-SIDS groups: the presence of thymic petechiae in SIDS (89.5%) compared with non-SIDS (47.7%) was highly significant ( P < 0.000001; OR 9.38 (CL 4.5 to 19.9), and their absence was more frequent in non-SIDS (52.3%) compared with SIDS cases (10.4%) ( P < 0.000001).

When we analyzed the gene expression data set, this pathway was also enriched highly significant ( p < 10 −6 ).

For consistency, we also examined this relationship using the 1000 Genomes phase II data and found similar highly significant relationship between N e for homozygous SNVs ( P < 10 − 6 ) (Additional file 1 : Figure S1).

In contrast, highly significant differences were observed among the crop species (F 2,18 = 615.70, p < 0.000001; Table 1 ).

The correlation coefficient (r = 0.44) was found to be highly significant (p<10 −6 ).

A very highly significant increase of Ang‐2 concentration ( p < 0.000001) was observed in CSF of MA patient in comparison with CTRL subjects (Fig. 1A ).

In such a comparison (Figure 1) it will be observed that the distributions appear quite different; the mean AFTPs have a highly significant difference (t = 10.6, P< 10-6, d.f. = 1.721).

The behavioral phases of flies released at peak versus trough temperatures showed non-overlapping distributions with a highly significant difference (t-test P < 10 -6 ).

Specifically, the evidence grading criteria were as follows: If the association was supported by a highly significant random-effects ( P < 10−6, a threshold considered to substantially reduce false positive findings) 10 – 13 , a sample size of more than 1000 cases, P < 0.05 in the largest study, I2 < 50%, absence of small study effects, a PI excluding the null, no evidence of excess significance bias, and P < 0.05

Overall, there is a highly significant relationship between spatial cluster size and dispersal syndrome across our 561 study species (Kruskal-Wallis, degrees of freedom [df] = 6, χ 2 = 64.3, p < 10 −6 ).

The difference between means of traffic exposure groups was highly significant (Wilcoxon test, p < 0.000001).

The analysis of discriminance revealed a highly significant discrimination between diabetic patients and controls (Wilks lambda: 0.27; P < 0.000001).

Velocity-dependent increase of the MEG gamma response frequency Consistent with our previous results [ 35 ] and those of other research groups [ 36 , 76 ], we observed a strong and highly significant increase in GR frequency with increasing velocity of visual motion in the combined TD and ASD sample (F (2, 80) = 149, epsilon = 0.70, adjusted p<1e-6, partial eta-squared = 0.79).

3 Results 3.1 Evaluation of the Visual Screening Test as Early Reading Predictor 3.1.1 Correlations Between Percentile at the Visual Search Screening Test Performed in Kindergarten and Z‐Score of 3rd Grade Reading Efficiency Figure 3 displays the correlation for the full sample (gathering children assessed at 3, 4, and 5 years old and categorized in percentiles) which appeared highly significant (r = −0.24, p < 10−6, n = 494).

We found the association between long sleep duration and increased mortality of lung cancer was highly significant in the random-effects models ( p < 1 × 10 −6 ).

In contrast, the majority (87%) of lncRNA hits identified were negative hits, and this enrichment in the lncRNA hit distribution was highly significant (permutation test p < 1 × 10 −6 ; Figure 3 A, right).

An umbrella review of systematic reviews and meta-analyses evaluating the association between environmental risk factors and AD showed that late-life depression and type 2 diabetes mellitus are the most significant; cancer, depression at any age, and physical activity are also highly significant ( p < 10 −6 ) in AD development.

Changes between baseline rest phase and acute mental stress phase were statistically highly significant for all self-assessment measures ( p < 10 −6 , two-tailed Wilcoxon signed-rank test).

The observed reductions with the extracts were highly significant (significance p < 1*10 –6 ).

This pattern persisted across different levels of significance filtering in the GWAS results, although it became more pronounced when restricted to highly significant variants (P < 1x10 −6 ) ( Fig. 4 a).

This correlation was highly significant ( p < 0.000001).

Lastly, kDGF was a highly significant multivariable predictor of a higher CCI, even after controlling for the four other significant multivariable predictors of this outcome ( p < 0.000001, Table 5 ).