“highly significant”

Upon initial analysis, the storage process demonstrated a highly significant effect (Hotelling multivariate p-value = 1 × 10 −6 ).

Similarly, the marital status distribution (35 single individuals out of 40 cases) showed a highly significant deviation from the expected proportion ( p = 0.000001), suggesting that single individuals are at notably higher risk.

In all cases, the post-hoc contrasts were highly significant (p-value < 1 × 10 −6 ).

Similarly, ‘IBD Region’ (left colon, right colon, rectum, sigmoid, transverse, ileum) showed highly significant associations in UC and CD ( p < 0.000001), indicating that anatomical location of involvement may be another important component of the molecular heterogeneity underlying IBD.

This analysis reveals a difference in the K A / K S distributions between intact copies and retropseudogenes (which may show low K A / K S ratios by chance), with a highly significant excess of intact copies for K A / K S < 0.5 ( Figure 2 ; p < 10 −6 , Fisher's exact test).

At 24 h (Test B), delayed cutaneous responses were again higher in phototypes I–II (1.01 ± 2.02) compared with phototype III (0.00 ± 0.00), with the difference remaining highly significant ( p < 1 × 10 −6 ).

We found the association between long sleep duration and increased mortality of lung cancer was highly significant in the random-effects models ( p < 1 × 10 −6 ).

The difference was highly significant ( P < 0.000001).

The inhibition of each infection by heparin was highly significant ( P < 10 −6 by χ 2 test, comparing infected and uninfected populations).

All 157 SNPs with highly significant associations ( P <1 × 10 −6 ) in this region, were in high linkage disequilibrium with rs188686860 and rs115635831 ( r 2 >0.90), and were located proximal (Hg19: 201,717,014-201,995,860) to the CASP8 gene ( Supplementary Table 15 ).

Planned comparisons revealed a similar Laterality effect in French and Spanish [ F (1, 120) = 1.78, MSE = 32.31, p = 0.19, η 2 = 0.005] but a highly significant difference between these two groups and the Arabic group [ F (1, 120) = 223.12, MSE = 32.31, p < 0.000001, η 2 = 0.65].

The difference between the sharpness indices of the native 2D images and the super-resolved images (both regularizers) was highly significant ( p << 10 −6 ) for both subjects, with the super-resolved images being less sharp.

Consistent with the reduction in peripheral blood myeloid cells, the reduction in contribution from Kat6a E/E ;Kat6b E/E fetal liver cells to bone marrow CMPs, GMPs and MEPs was highly significant (all P <10 −6 ; Fig.

In confirmation of our hypothesis, there was a highly significant, 9.4-fold, increase in the maximal tetanic force (7.5±0.94 g versus 0.8±0.2 g; p=≤0.000001) elicited by ONS in the engrafted OST group of SOD1 G93A mice at late-stage disease, compared to age-matched untrained SOD1 G93A mice (132.4±6.8 days versus 133±6.9 days; n=7 and 11, respectively; Figure 5C–G and Appendix 1—table 3 ), although OST did not alter contractile rate characteristics ( Figure 5—figure supplement 5A–C ).

(2016) but with eight different healthy controls, the overlap across the two independent studies (and platforms) was substantial and highly significant (p<1e-06), far exceeding any overlap obtained from 100,000 random permutations of patients and controls.

Following previous umbrella reviews, 13 we considered as convincing the associations with>1000 cases a highly significant association (p-value<1 × 10 −6 ), no large between-study heterogeneity, no evidence of excess significance bias or small study effects, and a 95% prediction interval excluding the null value.

For HR2, PON1 activity was highly significant (protective) in an unadjusted model ( p = 10 −6 ); continued to be highly significant in a collection of models adjusted for gender, age, and a set of covariates added one-at-time; and finally remained significant ( p = 0.0003) in a model adjusted simultaneously for all covariates of the dataset (gender, age, UAE, past CVD, DM, apoB, use of statins, anti-hypertensives, smoking, ethanol use, and eGFR).

Changes between baseline rest phase and acute mental stress phase were statistically highly significant for all self-assessment measures ( p < 10 −6 , two-tailed Wilcoxon signed-rank test).

For consistency, we also examined this relationship using the 1000 Genomes phase II data and found similar highly significant relationship between N e for homozygous SNVs ( P < 10 − 6 ) (Additional file 1 : Figure S1).

Results The statistical analysis of the Dice coefficients and the BLD values resulted in highly significant differences (p<10 −6 ) for the 5-mm and 8-mm local RRs vs the global, bony and 1-mm local RRs.

Highly significant differences in the levels of composite biomarkers were found between AD groups and normal controls ( p < 0.000001, one-way ANOVA), whereas differences in the levels of a single biomarker were only significant at the level of 0.001 (Fig. 4a–f and Supplementary Fig. 28 ).

SwinIR and SeD fell below clinically acceptable thresholds, showing scores near 1.0 and highly significant differences across all categories ( P < .000001).

An umbrella review of systematic reviews and meta-analyses evaluating the association between environmental risk factors and AD showed that late-life depression and type 2 diabetes mellitus are the most significant; cancer, depression at any age, and physical activity are also highly significant ( p < 10 −6 ) in AD development.

the nascent bond show that all of these active site dynamics are highly significant with p < 10 −6 ( Fig.

Besides the obvious highly significant effect of age on age at onset and at diagnosis of RBD ( p < 0.000001), we found a significant effect of treatment with antidepressants on age at diagnosis of RBD, with antiD+ patients being on average 6.6 years younger than antiD− patients, with a large effect size.