All were preserved with one or several ingredients listed in Annex V of the EU Cosmetics Regulation (EC 1223/2009), which was a highly significant difference compared to solid shampoo ( p < 0.00001, Fisher's exact test).
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Hypergeometric tests showed a highly significant overrepresentation of genes of the non-normalized modules in each normalized module (P<0.00001) consistent with similar networks being recovered by the two approaches.
Correlation analysis across six independent bulk transcriptomic cohorts (TCGA-PAAD, ICGC-PAAD-CAseq, GSE85916 , GSE79668 , GSE71729 , and EMTAB6134) demonstrated a highly significant positive association between THBS2+ CAF signature scores and T-cell exclusion scores (all p < 1 × 10−5), indicating that tumors with high THBS2+ CAF infiltration exhibit restricted T cell access to tumor nests ( Fig. 4 B).
Of these, five genes ( atp H, ndh K, psb E, rps 11, and rps 4) displayed highly significant variation ( P < 0.00001).
A linear regression model between vehicle occupants’ death rate and seatbelt noncompliance in our published data was highly significant ( P <.00001) ( Figure 1 ).
Comparison between the groups showed a highly significant difference in anxiety score reduction, with the compliant group demonstrating greater improvement (p<0.00001) Table 2 .
The combined p ‐values obtained for the three hypotheses tested were highly significant ( p < 0.00001) in all cases. 4 DISCUSSION Differences in quantity and quality of the progeny are the most obvious consequences of mating systems and sexual polymorphism, but they are not the only ones.
6b and 6f ) is highly significant ( p = 10 −5 ).
Results Nadi Shodhana Pranayama showed a significant decrease in ART (p = 0.01) and Bhramari Pranayama showed a highly significant decrease in ART (p < 0.00001).
The difference in classification performance between sexes was highly significant (Mann–Whitney U‐test, p < 0.00001, Figure 4A , effect size d = 0.8), showing a strong sex‐related bias in models trained without using ERP features.
There was a highly significant correlation between staining intensity and the percentage of positive cells for EGFR as well as pl85HER-2 (Spearman; rs=0.83, P<0.00001).
The overall effect of the combined subgroups (COI and no COI) was also highly significant for patients treated with BEVA ( p < 0.00001).
This study showed that duration of analgesia was 37% higher for Bupivacaine which lasted for up to an average period of 7.3 hrs which was highly significant (p=0.00001*).
There was a highly significant correlation in the methylation status of the MGMT promoter region and MGMT protein expression ( p < 0.00001, Fisher exact test).
The deviation from Hardy-Weinberg equilibrium is highly significant ( P < 10 −5 , Fisher’s Exact Test 40 ) with a complete absence of heterozygotes.
The paired Wilcoxon test showed highly significant (p < 0.00001) Δ T core ( t ) differences between the time-dependent core temperatures T core ( t ) of the following barrel pairs: artificial zebra versus grey horse, artificial zebra vs. grey cattle and artificial zebra vs. real zebra.
The p value is highly significant (p < 0.00001), indicating a strong association between disease severity (as per Modified H&Y staging) and the occurrence of OH.
Furthermore, a robust association between observed and predicted responses for TC degradation was evident from the highly significant regression model (p-value < 0.00001), high coefficient of determination (R2 = 0.9886), and well-adjusted R2 value (0.9780) 18 , 59 .
The strongest structure was among all populations (F ST = 0.098), followed by differentiation among the two ecotypes (F CT = 0.068) and then differentiation among populations within ecotypes (F SC = 0.032), and all were highly significant (p < 10 −5 , Table 5 ).
4 A2 ) showed that the suppression is highly significant during the cue period (Z^ = −7.74, P < 0.00001).
The Fst values were relatively high and reached highly significant levels (p < 10 −5 ) between populations from Tak (all collection periods) and Yala-Narathiwat (21.75%), and between Ubon Ratchathani and Yala-Narathiwat (19.44%), implying genetic differentiation or limited gene flow between these endemic areas.
However, year was highly significant ( P < 0.00001), while PI x year interaction was not significant ( P < 0.623).
1 , Supplementary Figure S1 ).The modules were numbered in increasing order from 1 to 30 according to scores of the clustering algorithm 15 (Supplementary Table S1 ); 1 is assigned to the module with the highest score (most densely connected to each other).Next, we assessed whether genes of the clustered terms are significantly interconnected in physical interactions by comparing each of 30 modules with randomly generated networks having the same gene number of the corresponding module and confirmed the highly significant inter-connectivity of them 12 (Supplementary Figure S2 , S3 , p < 0.00001), meaning that their components are not randomly distributed in the interactome.
This difference was highly significant when comparing each AUC avg group with placebo group ( P < .00001, Tukey test).
The heterogeneity test indicated a highly significant variance ( P < 0.00001, I2 = 94%), thus indicating the application of a random-effects model for the analysis.