“highly significant”

Heterogeneity analysis revealed highly significant heterogeneity (I 2 = 93%, p < 0.00001), thus a random-effect model was used for statistical analysis.

A new repeated measures ANOVA excluding the local recombination estimates for SNPs with MAF < 0.1 was applied and the differences in recombination rates between the groups remained highly significant ( P < 0.00001).

Increasing the ultrafiltration volume or dialysate flow led to a highly significant increase in IL-1ra and IL-6 clearance rate ( P < 0.00001).

There was a strong positive correlation between DAO and histamine levels in all the groups that was statistically highly significant ( p = 0.00001) (Table 6 ).

A posterior-dominant pattern of ‘neural slowing’ was observed, with increased theta band power in PD that was highly significant ( p < 0.00001), as well as a spatially similar concomitant decrease in gamma-band activity ( p < 0.00001)—in other words, an increase in low frequency activity and a decrease in high frequency activity.

Therefore, there is a highly significant difference in the expression of functional GABA B receptors on VTA GABA neurons compared to VTA dopamine neurons ( P <0.00001, Fisher exact test), making this property the most reliable pharmacological difference between GABAergic and dopaminergic VTA populations.

Estimation of the SNP effect from the haplotype effect Under the hypothesis that one SNP of each haplotype was expected to have a major effect on the recorded trait, direct observation of those haplotype alleles that showed a highly significant effect (P < .00001) on one trait allowed to select one SNP where the two alleles showed opposite effects on that trait.

The difference between DN-tail-tip and GFP control monolayer dextran influx was highly significant (p ≤ 0.00001), considering that TRITC-dextran was already present between cells upon initiating live image acquisition in DN-tail-tip experiments ( Figure 8D ).

In splenic macrophages from arthritic mice treated with TNFα targeting but not with control siRNA, we found a decrease of intracellular TNFα staining indicating effective silencing ( Figure 6b ).Overall, the effect of treatment on mean fluorescent intensity value is highly significant according to an ANOVA ( F = 17.061, P < 10 −5 ).

This difference was highly significant (Mann–Whitney U test, P < 10 −5 ).

The mean behaviour of these groups of genes in response to heat shock displays a highly significant positive correlation (Pearson r = 0.312, p < 0.00001, Spearman r = 0.314, p < 0.00001; electronic supplementary material, file S2), such that those mRNAs corresponding genes more distant from transcription initiation sites increase in abundance while those close to transcription initiation sites decrease.

These results were highly significant (p = 0.00001).

This effect size is also highly significant at a level of 0.01 ( P < 0.00001).

A highly significant positive correlation was found between the weight of male newborns and their mother’s weight ( r = 0.389; P = 0.00001), while no significant correlation ( r = 0.180; P = 0.0871) was found between the weight of female newborns and the weight of their mothers (Figure 1 ).

This superiority of RBZ and RBZ + Laser compared to laser treatment in terms of a positive effect on BCVA were highly significant (WMD = 5.65, 95% CI, 4.44–6.87, P<0.00001 and WMD = 5.02, 95% CI, 3.83–6.20, P<0.00001, respectively), with no heterogeneity identified ( Fig. 2A and 2B ).

Investigating this association in a cohort of 227 medulloblastomas, we found that loss of chr3p was highly significant when searching for genomic regions tightly linked with CT (Fig. 5c , two-sided Fisher exact test, p < 10 −5 and two-sided Chi-square test, p < 10 −8 , respectively).

To confirm that the reported effects are not isolated and support the structure of the comparisons shown, we ran Friedman tests as non‐parametric omnibus tests which yielded highly significant results (alpha band, p < 0.00001 , χ 2 = 115.93 , Kendall's W = 0.68 ; gamma band p < 0.00001 , χ 2 = 120.6 , Kendall's W = 0.7 ).

There was a strong relationship with sleep disturbance as indicated by highly significant correlations with all four SQS subscales (all p < 0.00001) but not with hours of sleep.

Overall, the mean ERC between all complement deficiency genes was 0.344, which yielded a highly significant p-value (permutation P < 0.00001) ( Table 1 ).

The conversion rate was 2.53% ( n = 133/5263) in the robotic and 11.94% ( n = 3874/32,442) in the laparoscopic group, and was highly significant to the favor of the robotic group ( p < 0.00001). 4.

This finding was statistically highly significant (Z = 5.44, P < 0.00001), supporting a strong association between the intervention and the outcome in cohort studies.

This difference was found to be highly significant (OR=5.55, 95% CI 3.47 to 7.65, p < 0.00001), as shown in Figure 5 .

Highly significant differences were observed, with 94% of COVID-19 positive pneumonia patients receiving remdesivir, compared to 46% in the COVID-19 negative pneumonia group ( P < 0.00001).

The first ranked ChIP-seq track found is the one against an overexpressed haemagglutinin (HA)-tagged MITF 21 , indicating a highly significant correlation between the E-box/MITF predictions and the ChIP-seq data (hypergeometric adjusted P -value<1.0e−05, Normalized Enrichment Score=31.2).

One group was enriched 20–30-fold relative to the GST negative control, with highly significant P -values ( P < 1 × 10 −5 ).