The difference is highly significant (X2 = 12X17, 1 df, P < 0-001).
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The indices of 4-8, 20-6 and 6-2 are highly significant (P < 0-001), the first 2 being obtained from nodular sclerosing Hodgkin's disease, and the third from follicular lymphoma of lympho- cytic type.
However, the average time of death of the 5/9 group I + C patients who died is 146 days post- relapse (because there were no late deaths) as against 291 for the 17/20 group I patients u'ho died. This second analysis could mislead the average reader into believing that there is highly significant (P < 0-01) evidence that chemotherapy worsens post-relapse survival.
The relative radiosensitivity of the tumour in the OH compared to FFC nlice, virtually a measure of the effect of the changed genetic 5700 = 1-4 milieu, can be expressed as the ratio of the two LDzio S, 3950 4 (+ 0-05*). The magnitude of this ratio compared to its standard error shows the difference in radiosensitivity of the two groups to be highly significant (p < 0-0001).
Similarity of gene expression between the two groups was highly significant ( p = 1.0 e-323).
Interestingly, the legal status across the two sets of states is highly significantly different (ChiSqu.Trend = 1503.6, p = 7.33 × 10 −321 ).
4 C) and, although the overlap is small, it is highly significant compared with randomly reshuffled genomic regions ( P <10 −320 ; Fig. 4 C).
Using (Log 2 [ β /(1 – β )]=0) as cutoff, Fisher’s exact test shows highly significant interdependence between gene expression and DNA methylation in the promoter region ( P = 4.5E-315) ( Figure 3 A).
A χ 2 test ( supplementary table S1 , Supplementary Material online) revealed a highly significant overrepresentation of new–new and old–old node connections within the MMM12+ network, whether using OMA groups ( P < 1.1E – 311) (as is shown in fig. 1 B ) or MAP clusters ( P < 1.1E – 311).
All of the overlap between pairs of cohorts mentioned above was highly significant (Fisher’s exact p < 1×10 -308 ); however, a caveat of this analysis is that the four brain regions were sampled from the same set of individuals.
We note that the P -value of the Spearman correlation was highly significant in every single case ( P -value <2e-308) because of the large number of data-points.
22A ) and revealed a highly significant correlation of effect sizes (Spearman’s rank correlation) between both types of variants ( r = 0.85, P < 2.2E−308).
In consistent with this, the association between rs4759076 and mean platelet volume is highly significant ( p = 2.2 × 10 −308 ) [ 30 ].
The difference between the abundance of MIKC-only and non-MIKC-only prospective tetramers is highly significant, according to a Mann-Whitney U test ( U = 117.5; p < 2.6 × 10 -308 ).
Treatment of WT U-2 OS cells with arsenite showed a highly significant and global shortening of RNA upon stress (Mann–Whitney, p-value<10 –307 ) in stark contrast to ΔΔG3BP1/2 cells that showed substantially less shortening (Mann–Whitney, p-value<10 –5 ) ( Figure 6e , Figure 6—figure supplement 1g and h ).
The analysis of the pathogenic variant in the three main breeds with 96 cases resulted in a highly significant association (p = 6.62x10 -303 ) with CMO.
Prior to pleiotropy test, analysis of genetic correlation between the traits showed a highly significant genetic correlation between t-tau and p-tau181 ( p = 6.99 × 10 −303 ), however, correlation of these two traits with Aβ42 was not significant (p Aβ42 vs t-tau = 0.25 and p Aβ42 vs p-tau181 = 0.27).
TM content and topology in viral and microbial proteins The distributions of membrane proteins by the number of TM segments in representative sets of prokaryotic and viral genomes show striking, highly significant differences ( p -value < 1e-300 by Chi-Squared test and <2e-16 by Mann-Whitney-Wilcoxon test) whereas the archaeal and bacterial distributions are indistinguishable (Fig. 3 ).
The chi-square test value was highly significant with a p -value <1.0e−300.
Analysis of the sequenced reads using the peak recognition algorithm of Model-based Analysis of ChIP-Seq (MACS) [35] gave a highly significant overlap of 11,369 peaks from three profiles ( P <1E-300) ( Figure 1A ).
All of these degrees of overlap are statistically highly significant ( p -value <1 × 10 –300 ).
Association analysis of normalized methylation data (beta-values) from 391,885 CpGs revealed 11,010 sex-methylation associations (SMAs) ( p < 1.26E−07) with some of them being highly significant ( p < 1E−300).
The 6-bp difference from in vivo and nonlinked experiments is highly significant ( p <10 −300 , WMW test) and shows a major role for chaperones [48] in positioning H2A.Z nucleosomes, which is confirmed by the in vitro reconstitutions in the presence of ACF1 and Nap1 [2] .
Unsupervised analysis identified 2 subgroups (c8.1 and c8.2, Fig.3a ) defined by a gene list which demonstrated highly significant overlap with that defining the prognostic subgroups in both AAV and SLE (hypergeometric p<1×10 −300 ).
We found a highly significant correlation ( r = 0.802 , P < 10 − 300 , Spearman correlation test; Supplementary Figure 1a) between the true and estimated loss rates.