“highly significant”

This presentation demonstrates the high degree of similarity in the gene expression response, and the numerical correlation between the responses was highly significant (p <10 -214 ; chi-square test).

The Kruskal–Wallis test revealed highly significant differences in elevation distributions across species ( H = 1112.88, p < 2 × 10 −212 ), indicating pronounced elevational structuring within the mammalian community.

However, here we found that ToxoNet exhibited a highly significant overlap in protein interactions with both T . brucei (283 common interactions, p = 6.4E-204) and Plasmodium (450 common interactions, p = 0; S6B Fig ).

Among the 12 genes related to hormone secretion, Vgf (nerve growth factor inducible) showed a highly significant increase in expression in GCGR-KO α-cells (Log 2 FC = 1.38; p = 2.21E-203) (Fig. 4a ).

In the present study, we found a highly significant enrichment of long TRD sequences in RA compared to healthy individuals ( P = 7.91e − 202, Additional file 32 : Fig S7).

This finding was further supported by scatter plots, which demonstrated a highly significant level of connectivity within the turquoise module (cor = 0.77, P < 1e-200, Fig. 3 E).

This module contained 753 genes, which showed a highly significant association with nmSCs infiltration levels (Cor =0.88, P<1e−200; Figure 2C ).

Notably, chemical effects on cell-level SRPs were reliably detected across varying signature lengths, particularly in the UPR, where chemicals such as Brefeldin A, Cycloheximide, and Troglitazone exhibited highly significant length-dependent effects ( p < 1e-200) despite their small effect sizes.

Within the brown module, a highly significant correlation was observed between gene significance (GS) and module membership (MM) (correlation coefficient = 0.92, p < 1e − 200) (Fig. 2 D).

In total 689 genes appear in both lists, which represents a highly significant overlap ( P value <1E-200) (Figure 3a and Additional data file 2 , Table S2).

These tendencies were observed in both the 1645 group and the 239 group (data not shown) and were highly significant by Wilcoxon's rank-sum test (both of them showed P < 1e−200).

The analysis shows clear, highly significant (p-value < 1e-200) enrichment with matching FC signs between our SCZ analysis and reference PsychENCODE SCZ data (Supplementary Fig.

Steady state mRNA levels had a highly significant ( p < 10 −197 ) correlation with mRNA stability ( Fig. 2c ).

This trend is, again, present and highly significant in the experimental data ( 52 ) (logistic regression with two-tailed t -test, P = 1.5 × 10 − 195 , n = 7 , 311 ; Fig. 3 D , Right ).

The strong positive correlation between the cophenetic pairwise distances and proteomic dissimilarities is highly significant (rho = 0.6540, p-value = 1.9599e-195; r = 0.7291, p-value = 7.6776e-265), suggesting that the representative tree illustrates quite well the differences in the proteomic properties.

The shift for “No IC” and “Any IC” was also both highly significant ( p = 7.79406e–193 and p = 5.31155e–78, respectively) ( Table S3 ).

Consistent with our previous results, we found a small but highly significant enrichment of dDMPs becoming hypomethylated with cortex development ( n = 28,780 [56.5%], p = 1.61 × 10 −191 ) with the mean effect size being significantly greater for hypomethylated dDMPs than hypermethylated dDMPs (change in DNA methylation [%] per week: hypermethylated dDMPs = 1.03, hypomethylated dDMPs = −1.53, t test p < 1 × 10 −320 , Figure S3 ).

However, the correlation in expression of CD14 and K2 was highly significant (p = 8 x 10 −191 ) compared to that of CD19 and K2 (p = 0.065) at 1 dpi.

50 With regard to the highly significant overlap ( P = 1.9E − 184) with the dataset comparing MDA-MB-231 cells vs MCF10A cells, it was striking that the majority of the 2385 overlapping gene features showed a negative correlation ( Fig. 2E ), indicating that more than 2/3 of the transcriptional alterations induced by low density cultivation of MCF10A cells overlapped significantly with MDA-MB-231 cells.

While about 8% of the worm genome is arranged antisense to another gene (Thierry-Mieg & Thierry-Mieg, 2006 ), approximately 35% of increased and decreased transcripts were arranged in this manner, representing a highly significant enrichment ( P = 5.3 × 10 −181 , hypergeometric distribution (hgd)) (Fig 1 B).

A One-Way ANOVA was performed, and the results indicate a highly significant difference between the ligand groups (P-value < 6.6718 × 10 −177 ).

This trend was confirmed across two additional independent sampling replicates ( n = 10,000 molecules per replicate), indicating that the effect is not attributable to stochastic variability. Across all runs, the improvement in QED at T = 0.6 remained highly significant (one-way ANOVA p < 10 –175 ; Kruskal–Wallis p < 10 –180 ), with a similarly significant reduction in structural alerts ( p < 10 –2 ).

Analysis of CpG sites positively correlated across all tissues revealed ‘nervous system development’ as a highly significant gene ontology (GO) term (P = 2.0 × 10 –171 ).

When test and training data were from the same day, estimates of mouse location were excellent (median error nearly always <7 cm) and highly significant compared to shuffled test data ( P <10 -160 ; Kolmogorov-Smirnov test).

In the subgroup comparison between the high LDL-C and CAD subgroups, a highly significant difference was observed for LDL-C ( P = 5.8×10 -158 ) because the high LDL-C subgroup was originally defined using LDL-C levels.