“highly significant”

Another problem is that if a secondary variable shows a clinically important effect or is highly significant (for example, with P < 0.0001), as one of the secondary outcomes in Baggot et al.

The association between phaseolin type and cluster membership was highly significant and nearly complete (χ 2 = 174.72; df = 1; P < 0.0001; Cramér's V = 0.93).

The lactation number was highly significant ( p < 0.0001) when comparing LCS groups, as well as the age of the animals ( p < 0.0001).

The overall prognostic value of target status in MDST models was estimated via binomial testing of observed response variables (predicted versus unexpected) in all trials (talazoparib + trametinib) and found to be highly significant (80% correct prediction in n = 10 trials, P < 0.0001; fig.

A statistically highly significant correlation was found between changes in 99m Tc-Annexin V tumor uptake and clinical response (r 2 = 0.62; P < 0.0001).

A highly significant trend emerges from the data (Cochran–Armitage Trend Test = −4.72, p < 0.0001): as the absolute value of the Tmax/Dmax ratio increases, the physiological outcome decreases, from 52.4% in the first quartile, 33.3% in the second quartile, 14.3% in the third quartile to 0.0% in the last quartile, respectively.

For the SIADH/cancer subgroup, subjects on tolvaptan exhibited a highly significant improvement in this parameter ( P < 0.0001) relative to placebo to day 4 (5.0 vs. −0.3 mEq/mL) and to day 30 (6.9 vs. 1.0 mEq/L) (Fig. 2 ).

Results White-squid coloration changing according to substrate Our selected mathematical model revealed a highly significant interaction between the fixed effect of substrate (Fig. 3 ) and all the measured RGB color channel values (p < 0.0001) on the head that appear all highly positively correlated with each other and with the mantle (r > 0.94, p < 0.0001; Supplementary Table 1 ) and matching the destination substrate (Fig. 4 ).

There were highly significant correlations ( r = 0.89, p < 10 –4 in Paris) and good intraclass correlation coefficients ( R = 0.89 in Paris) between the two series of values.

Results Applying a vote‐count strategy to search for the intersection of genes reported in multiple independent studies with a consistent fold‐change direction, followed by a Monte Carlo simulation, we identified 528 highly significant differentially expressed multi‐study genes ( p < 0.0001; 10,000 simulations).

However there was highly significant difference between different age groups in VI [p<0.0001, χ 2 (df) = 162.6(18)].

The most highly significant differences with a p < 0.0001 are identified between the two 3T devices of the different manufacturers.

These differences were highly significant ( p < 0.0001).

Moreover, a drastic fall was observed in case of IgG4, where the difference became significant as early as on day 30 ( P = 0.0027) and was highly significant on day 365 ( P < 0.0001).

Results In terms of detection, participants successfully detected 95±6% (average±STD) of the Duck-under obstacles in the test trials while using the EyeCane, in a highly significant manner over the control while using the white-cane alone 13±30% ( p < 0.0001) (see Fig. 3A ).

As expected [ 11 ], a significant correlation was found between PAF-AH and total cholesterol ( r = 0.25; p = 0.032), a stronger direct correlation with LDL ( r = 0.46, p < 0.0001) and a highly significant inverse correlation with HDL ( r = −0.45, p < 0.0001).

Spheroid ciliary beat frequency discriminated highly significant between healthy controls (9.3 Hz) and PCD patients (2.4 Hz) ( P < 0.0001).

3c ) is highly significant ( p < 0.0001).

When animals that received nerve injury or pharmacological block were pooled together (one-way ANOVA; F(3,60) = 7.3, p = 0.0003) the increased responsiveness reached significance already in the first protocol after deafferentation (Dunnett test; p = 0.0289), transiently lost significance in the second protocol (p = 0.12) and was again highly significant in the third protocol (p<0.0001).

Further analysis of the 14 MRD-positive samples showed a highly significant correlation between the 10 log-transformed MRD data of both measurements ( R 2 = 0.999, P < .0001; slope = 1.0) FIGURE 1A ).

Analysis of biopsies from all 25 NB patients revealed a highly significant correlation between stage IV NB and nuclear localization of FOXO3 (P<0.0001) and pFOXO3-T32 (Figure 1B , ANOVA).

The results presented in Table S3 showed that the model was highly significant (F-value = 69.52, p < 0.0001).

The differences in Ln probability of the data between the two most likely scenarios (#1: length-at-age as prior, k = 2 and #2: sampling location as prior, k = 2; Fig 4 ) were highly significant (Steel-Dwass All Pairs, z = 5.7, p <0.0001).

Using GREAT, we found that about 77% of the genes associated with active TFAP2A peaks are also associated with active MITF peaks, a highly significant overlap (hypergeometric test, p<0.0001) ( Fig 3D ).

A highly significant increase in retinal thickness with decreased cell density was observed when comparing the control and 3 dpi (P < 0.0001).