“highly significant”

Comparing the individual means of clinical outcomes using paired t-test, highly significant improvement ( p < 0.0001) was observed for all clinical outcomes in the intervention group; however, only some significant improvement for LDL-C ( p = 0.043) and DBP ( p = 0.048) was observed in the control group.

The rise in seroprevalence between 2023 and 2025 was highly significant across sexes, regions, and provinces (p < 0·0001; Table 2 ).

This difference was highly significant for the screen detected cancers (P <0.0001).

There was no statistical significant difference in the evolution of the HHS between the three groups (Table 2 ). Viscosupplementation provided a highly significant pain reduction in the Adant-group ( P < 0.0001), a significant pain reduction in the Synocrom-group ( P < 0.05) and a pain reduction that did not reach significance in the Synvisc-group ( P > 0.05).

Analysis of variance showed highly significant variation due to year-by-genotype interaction effects ( p < 0.0001) in both HRP and CGP ( Table 2 ).

Survival analyses showed highly significant associations between early interim PET and progression-free survival ( P < 0.0001) and overall survival ( P < 0.03).

Fisher exact test demonstrated a highly significant enrichment ( P < 0.0001, odds ratio: 716.8, 95% confidence interval: 179.0–2871).

Mean CD3 + T cell as well as CD4 + T cell counts were low in group 1 (426 ± 168 × 10 6 /L; 373 ± 142 × 10 6 /L) and normal in group 2 (1176 ± 339 × 10 6 /L, 884 ± 248 × 10 6 /L) with a difference that was highly significant ( p < 0.0001).

With regard to convergent validation, the correlations of BSI score with ESS and THAT scores were medium and highly significant ( r = 0.47, p < 10 −4 and r = −0.40, p < 10 −4 , respectively).

albicans , where this reduction was highly significant ( p < 0.0001).

A highly significant ( p < 0.0001) increase in droplet size was detected for (F1) after 60 days of storage, increasing from 1099.0 ± 33.0 nm to 1609.0 ± 35.1 nm.

A GLM with a negative binomial distribution with a log link function showed a highly significant positive effect of nest type on the number of trips per female [slope = 2.902, t = 7.078, P < 0.0001, dp = 1.119; dp is the dispersion parameter of the model, and when this is 1, the dispersion of the data from the model is within the predicted variance from the model (meaning the model fitted well to the observed data)].

However, when the fertilization rates were adjusted for the mature oocytes (metaphase-II oocytes), there was a highly significant difference in fertilization rates in favour of the group with SDF levels < 15% where the women were in the younger age grouping of <35 years (78.4% vs. 73.0%; p < 0.0001).

The statistically highly significant differences observed compared to the positive control (Triton X-100, ~100% haemolysis, p < 0.0001) confirm that the observed effect was not non-specific but reflects the absence of an intrinsic haemolytic potential of the collagen material functionalised with P. nigrum extract (P3–P5, Figure 11 a).

Highly significant IOV was demonstrated for CT based contouring of the tumour bed (p < 0.0001), while agreement was high for the MRI-based approach.

As anticipated from the SR2508 urinary excretion data, the relationship was highly significant (r = 0.626, P = .0001).

In the seated position, a moderately strong positive correlation was observed (r 2 = 0.34), which was highly significant ( p < 0.0001) ( Figure 3 ).

Similarly, a highly significant (**** p < 0.0001) hypersensitivity to cisplatin even at a low dose (50 μM) was observed in the smc-5/6 mutant worms ( Figure 3 D; Table S8 ).

This revealed a highly significant difference in the frequency of the three genotypes between the dead and alive mosquitoes (chi-square = 28.8; p < 0.0001) ( Figure 5 ).

A highly significant interaction between treatments and the cut number was noted (P < 0.0001).

The association between MP-signature category and clinical category was highly significant (p < 0.0001).

Additional association analyses of LCN2 and MMSE scores including all groups with cerebrovascular disease (SVDND, VCIND, and VaD) showed highly significant negative correlations in cohort 1 (cc = −0.55, p < 0.0001, Fig. 3c , Spearman correlation test) and cohort 4 (cc = −0.56, p = 0.008, Fig. 3d , Spearman correlation test).

The data suggest a progressive mean rise in serum PLAP-like AP with increased smoking. This trend is highly significant (P=0.0001) as determined by a Wilcoxon rank regression test (Cuzick, in press).

This difference was highly significant (p < 0.0001; ANOVA test with Bonferroni post-hoc).

There was a significant heterogeneity among studies I 2 = 88.7% (95% CI: 76.3–94.6%), τ 2 = 17.32, and a highly significant Q -test ( p < 0.0001) ( 14 , 17–20 ).