“highly significant”

These differences in the percentage of cells with naive phenotype between day 0 and nadir, and between nadir and plateau, were highly significant (p = 1.99 × 10 −50 and p = 2.69 × 10 −38 , respectively, by paired t test).

As a group, haplotype-specific FIRE scores for these 124 peaks carried highly significant differences between their corresponding haplotypes (paired t test, p < 2 × 10 −50 , Figure 4 D).

This result was also reflected in our highly significant Pearson's correlation analysis of the cumulative deletion read % between Splice-Break and MitoDel (Pearson's r : 0.950; P = 2.98e −50 ) ( Supplemental Figure S14J ).

Overall, population differentiation between basins along the first eigenvector was highly significant ( p ‐value = 5.4 × 10 −50 : summed across AMOVA comparisons). 3.4 Isolation and migration analysis reveals gene flow between divergent populations The unconstrained model, M‐mode in IMa2p, estimated a population splitting time parameter t of 0.29 (HiPt = 0.299, HPD95Lo‐Hi: 0.253–0.351).

This overlap is highly significant ( P = 6 × 10 -50 ) and substantially greater than with any other signatures we tested (Table 1 ).

Using 14–19 months of cumulative 24/7 home-cage activity recorded with a non-intrusive technique, evidence is here provided for a highly significant circannual oscillation in spontaneous activity (1–2 SD of the mean, on average 65% higher during peak of highs than lows; P = 7E−50) of male and female C57BL/6 mice held under constant conditions.

Comparing the inferred “age/maturity” of the individual B-cell cluster showed highly significant differences between the three nonmature B-cell subpopulations (Kruskal-Wallis test, p =9.84e-50).

Finally, the region of residence presented a highly significant association ( p < 10 −49 ), with a minimum expected value of 21,573, indicating a strong relationship between the place of residence and the distribution of maternal and late deaths, as shown in Table 3 .

Comparison with our dataset of ERG-regulated ASEs revealed that a highly significant proportion (132/410; 32.2%, P < 10E–50) of ERG-regulated ASEs were also sensitive to RBFOX2 knockdown (Figure 3D ).

For example, of 596 genes in cluster 6A ( Figure 6 ) ( R 2 =0.505), 165 were involved in the process of worm growth according the Gene Ontology annotations, representing a highly significant enrichment of gene function in this cluster ( P < 10 −49 ) (Supplementary Data).

Intriguingly, there was a highly significant region × chromosome interaction ( P = 2.35 × 10 −49 ) effect at the exon-level but not at the transcript-level ( P = 1.00).

This difference was highly significant ( P = 4.3E-49 in chi-square test; Supplementary Dataset S1).

These differences were highly significant across all immune parameters (Kruskal-Wallis P < 10 − 48 for all comparisons).

Consistent with our prior publications 14 , 15 , we found clear suppression of EWS::FLI1 induced targets that was highly significant at the TES with both LCE ( P = 1.1e-48) and HCE ( P = 1.5e-33)(Fig. 3b ).

Among CpG sites distinguishing current smokers versus never smokers in lung adenocarcinoma at P < 10 −4 (n = 296 sites), we observed highly significant enrichment for the adult blood signature at P = 1.2 × 10 −48 .

The model exhibited excellent discriminative power with a C-index of 0.901, and highly significant statistical results ( p = 1.207 × 10 −48 ).

This was a highly significant, greater than threefold enrichment (hypergeometric test p = 1.5 × 10 –48 ) of these families compared to their representation in the genome overall.

The UCP2–CD68 association remained highly significant after adjustment (partial ρ = 0.524, p = 1.80 × 10 − 48 ), confirming that the relationship between UCP2 expression and macrophage infiltration is not a spurious consequence of tumour purity variation ( Supplementary Fig.

The association between α 5 and phalloidin staining was highly significant ( P = 3.32 × 10 −48 ) ( Figure 1(c) , Table 1 ).

Comparison of the co-expression profile of CHRNA5 expression across 59 CCLE breast cancer cell lines with the logFC values from CHRNA5 RNAi profile revealed a highly significant negative correlation and association (r = -0.33, p = 3.8E-48).

Error t value Pr(>|t|) topME $ logFC -0.738 0.0472 -15.7 6.17e-48 > abline (RNAvsME, col = "red" , lwd = 2 ) The negative association is highly significant ( P = 6 × 10 − 48 ).

In addition, allele frequencies derived from the pooled sequencing experiment were compared to those derived from all individuals in the phase II genotype data and revealed a highly significant correlation (r = 0.971, p < 6.58x10 −48 ), further supporting the validity of the pooled sequencing approach.

When restricted to the 3,137 EUR cases with a PheCode probability >0.80 and their 12,548 matched controls, the 90-SNP weighted PRS was highly significant (odds ratio [OR] = 1.82 [95% confidence interval: 1.68–1.97]; p = 8.0 x 10 −48 ).

As it turned out, there is a highly significant association between induction in both systems (Fisher’s exact test p value = 1.3, 10–47).

A statistical comparison using Cochran's Q test revealed highly significant differences among the models (Q = 235.5, df = 7, p = 3.27E-47).