“highly significant”

A GEE analysis, with robust SEs, adjusted for age, sex, cognitive state, APOE‐ε4 status, years of education, and recruitment site, indicated a highly significant overall group effect on BAGs ( χ 2 (4) = 156.07, p < 10 − 32 ).

The correlation is highly significant (χ 2 = 150.17 for df = 3, giving P = 1.20 × 10 −32 ).

We found a highly significant overlap between them (265 pairs, p = 1.4E−32, Fisher exact test, Fig. 6c ).

This is a 200-kb region centering at a highly significant risk SNP rs12579077 ( P = 3.4 × 10 −32 ) 2 kb upstream of IGF1.

When excluding the same proportion of transcripts as above (57.5%), but considering this time the X chromosome and autosomes separately, the difference of median expression levels between X-linked and autosomal transcripts became highly significant in both sexes (6.82 vs 7.91, P <10 −31 in males; 6.85 vs 7.91, P <10 −30 in females).

Importantly, a mixed-effect model demonstrated a strong and highly significant interaction between groups and time for both accommodative eye vergence (F[1, 5,403] = 137.99, p = 1.7 × 10 −31 ) and accommodative pupil constriction (F[1, 5,403] = 126.56, p = 4.9 × 10 −29 ).

Between the two datasets of upregulated genes, 739 genes are upregulated in common, which is highly significant in a chi‐squared test for independence ( P = 1.739e‐31; Fig. 4c ).

The genes that show female-bias in all four species are highly enriched on Müller A, relative to an expected uniform chromosomal distribution, and this excess is highly significant (chi squared test, p = 2.06x10 -31 , Fig 3A and S2 Table ).

When contrasting the associations of α44C and Q between high and low risk subjects, their differences of risk and resistant associations were highly significant (exact Fisher’s p-value = 2.16*10 −31 and 1.92*10 −19 , respectively).

We also found highly significant positive genetic correlations between all phenotypic pairings (risk-taking/BIP: r g = 0.33, p = 2.35e −31 ; risky behaviours/BIP: r g = 0.24, p = 7.50 −16 ; risk-taking/SCZ: r g = 0.22, p = 7.41e −16 ; risky behaviours/SCZ: r g = 0.16, p = 2.08e −10 ), replicating previous findings [ 8 , 33 ].

A likelihood-ratio test to discern the association of the rs1426654 SNP to skin pigmentation, in addition to the influence of sex and population (caste), showed a highly significant effect of rs1426654 genotype on skin pigmentation (p = 2.4×10 −31 ) with an odds ratio of 26.2 (95% CI 12–67.5) for the A allele.

The results confirmed that the shift in the run-on ratios produced by rpb9Δ was highly significant (0.66 log 2 units in average, P = 2.54 × 10 –31 ) ( Figure 4 A).

In terms of the regulatory feature group, these 586 CpGs had over-representation of "Promoter Associated Cell type specific" elements ( p = 1.40e-04) accompanied by highly significant under-representation of "Promoter Associated" elements ( p = 2.94e-31), suggesting that the observed hyper-methylation pattern involves tissue-specific promoters.

Concordance of the direction of the effect of the largest variance component was also highly significant ( p = 5.71 × 10 −31 , Supplementary Table S3 ).

The hit SNP is in high LD with this common 2-base pair deletion (labelled as chr17:44102741:D in 1000 Genomes or as rs67759530 in dbSNP) within the probe ( r 2 = 0.91, minor allele frequency = 23%), giving rise to a highly significant association in the Illumina HT12 data set ( P -value = 8 × 10 − 31 ).

The correlation between the trial-by-trial change of phasic pupil dilation and that of absolute movement error for the group-averaged data was highly significant ( r = 0.64; P = 8.97 × 10 31 ; bootstrap 95% confidence interval: [0.43, 0.80]), suggesting that the phasic pupil dilation may reflect error size.

Vaccination also resulted in a highly significant improvement of average daily weight gain (+ 46 g/day; P = 9.55 × 10 -31 ) and carcase weight (+ 1.25 kg; P = 4.54 × 10 -05 ) as well as a shortened fattening period (-8 days; P = 2.01 × 10 -45 ). status released display-pdf yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Received 2008 Aug 18; Accepted 2009 Jan 7; Collection date 2009.

Thus, we used HOMER analysis for known motifs, revealing highly significant consensus motifs such as NRF1 ( P = 10 −30 ) and ZBTB33 ( P = 10 −24 ) ( Fig S6A ).

The purple regression line shows the highly significant correlation with log(income) that has been previously identified for the Gallup data ( P < 10 −30 ).

In areas where the absolute value of log2FC was larger than 2, highly significant genes (-log10( p -value) > 30) were primarily enriched, suggesting a high degree of consistency in differential expression patterns across various data sources.

Logistic regression models predicting each treatment from diagnosis yielded highly significant associations (BH-adjusted p < 1 × 10 −30 ; Supplementary Data 5 ), indicating that diagnosis and treatment are not independently distributed.

Correlations between video tracker drifts and their search coil counterparts were moderate (average vertical ρ = 0.58 ± 0.09; average horizontal ρ = 0.51 ± .09) but highly significant (all p -values < 10 –30 ).

Functional enrichment analyses yielded major clusters for transcripts increased in ICD, including “collagen/extracellular matrix(ECM)”, “ECM-receptor interaction/PI3K-AKT signaling,” “inflammatory bowel disease”, and “Toll-like receptor signaling pathway.” Upstream regulator analysis revealed well-known inflammatory regulators interferon gamma (IFNγ), tumor necrosis factor (TNF), interleukin-1 beta (IL1β), and interferon alpha (IFNα) as highly significant (− log( p -value) > 30) in ICD animals relative to controls.

Suppression of PAPD4 also led to a highly significant reduction in miRNA expression, (t-test adjusted p value <1×10 −30 ), although the median relative miRNA expression value of 0.71 in siPAPD4 cells was of a smaller magnitude than observed from TUT1 suppression.

Figure 2a shows that there was a highly significant difference between the two groups, with a mean variance explained by individual of 74 % for the strong-eQTL group, and 65 % for the weak-eQTL group (ANOVA, p < 10 −30 ).