“highly significant”

africanum found that SIT 181 was always detected as a highly significant emerging strain (p<10 −30 –10 −31 ), followed by several other strains ( Table 2 ).

Notably, many of the highly significant GO terms are related to immune function and inflammation such as GO:0002376, immune system process [ P < 1e−30 both comparisons] and GO:0006954, inflammatory response [ P < 1e−30 both comparisons] (Fig. 6 A, Supplemental Table 1 ).

For example, in a recent meta-analysis of published studies, Li and colleagues (2011) reported that the association between rs1229984 and alcoholism is highly significant ( P < 10 −30 ) in Asian populations.

(Of note, the EMN estimation was repeated across different p value thresholds [i.e., defined as the limit of the top 0.5% p values and top 0.3%], obtaining consistent results across all thresholds, with strong highly significant correlations with the original EMN values [all r ~ 0.84, p < 10 −30 ].) Next, taking the 7718 values as data, we used a novel contrastive trajectories inference (cTI) algorithm to aggregate the DNAm data by identifying the trajectories of individuals aligned/ordered with the severity of epigenetic alterations hypothetically associated with maternal neglect.

Discussion Our GWAS across two cohorts of smallpox vaccine recipients, totaling just over 1,600 individuals, identified a highly significant (p < 1 x 10 −30 ) association signal from a region on chromosome 5 that was linked to significant inter-individual variations in IFNα response to in vitro stimulation with vaccinia virus.

The negative association between the changes at ZGA and upon Snrpb/d2 overexpression is highly significant ( P = 1.1 × 10 −30 , binomial test), suggesting that higher Snrpb/d2 levels before ZGA maintain alternative exon patterns in a more pre-ZGA state, a trend that was also observed for all exons together (fig.

For example, Pfam domains exhibit a highly significant, negative correlation between domain promiscuity (see Methods ) and sequence identity (ρ = −0.21, p = 2.08 e −30 , Spearman test).

Functional analysis also implicated olfactory activity as a highly significant ( P = 2.310 × 10 –30 ) function of the top 100 most saturated downregulated genes.

Across cell types and haplotypes, we found a positive and highly significant correlation (Pearson correlation; cell type: p = 2.36 × 10 −30 , haplotype p = 6.76 × 10 −4 , Fig. 7d ) between gene expression fold change and chromatin loop fold change, and between H3K27ac fold change and loop fold change (Pearson correlation; cell type: p = 6.6 × 10 −211 ; haplotype: p = 4.63 × 10 −5 , Fig. 7e ).

In contrast to the above mutation hotspots, phosphosites in TP53 termini appear as highly significant mutation deserts (three pSNVs observed, 67±8 expected, P =2.8 × 10 −30 from ActiveDriver).

Specifically, M186 was enriched (Adj p = 3.8e−03) for class-switched memory B cells ( BANK1 , IGHA2 , PAX5 , and SPIB ), whereas M181 showed highly significant enrichment (Adj p = 3.6e−30) for plasma cells ( FCRLA , HERPUD 1, JCHAIN , MZB1 , TNFRSF17 , and multiple V region genes).

The model demonstrated a good fit (Pseudo R 2 = 0.4949) and a highly significant overall model effect (Log-Likelihood Ratio [LLR], p = 4.691e-30), supporting the robustness of these predictors.

Expression level correlation between milk cell miRNAs and skim milk miRNAs The average miRNA expression levels correlated between MC and SM with a highly significant (p = 4.8 E-30) correlation coefficient of 0.795 ( Fig 2A ).

The GWAS gave a highly significant peak for the ss2019324576 variant ( P -value = 6.436e-30, after Bonferroni correction for multiple testing), whereas all other SNPs were not significant ( P -value > 0.05, after Bonferroni correction for multiple testing).

The strongest signal according to the PP4/PP3 was identified for rs2453555 at 9p21.2 (PP4/PP3 = 82.5), which was highly significantly associated with ALS risk (GWAS p = 6.5 × 10 −30 ), and at the same time served as a highly significant eQTL of C9orf72 in the pituitary gland (eQTL p = 4.4 × 10 −12 ), strongly suggesting a causal relationship ( Figure 3B ).

We found a highly significant correlation between the Magenta module eigengene (based on 76 probes) and strain status ( r = 0.99, p < 1.0e-29).

The correlation was highly significant ( ρ = 0.7304, p < 10 −29 ) and within this set the outliers (points which depart from the diagonal) were pairs of words relating apple to other concepts: apple-orange, apple-green, and apple-salad, which are more similar in Spanish than in English.

The increase in correlation coefficient is highly significant ( p -value < 10 -29 ) (Materials and Methods), arguing that our non-linear correction to the whole proteome abundances has increased the accuracy of these estimates.

In analyses of WTRadjBMI in macaques, BMI was a highly significant contributor to phenotypic variation in WTR (P=1.2 × 10 −29 ), and together with effects of age and sex accounted for a substantial proportion of its phenotypic variance.

The enrichment of 15q13.3 microdeletions within neurodevelopmental disorder-affected and ASD-affected case subjects (0.4% combined in NDD and ASD case subjects; 0.004% in control subjects) is highly significant (p < 1.30 × 10 −29 ).

Muzzle colour Single marker analysis that was run considering separately all three phenotypic classes (pink/pale, grey and black muzzles) identified a peak of highly significant markers ( P = 1.41 × 10 −29 ) on BTA18 within the melanocortin 1 receptor ( MC1R ) gene (Table 2 and Fig. 3a ; Table S1 ).

In total, 15 lifestyle factors were observed to interact with GS BMI , of which alcohol intake frequency, usual walking pace, and Townsend deprivation index, a measure of socioeconomic status, were all highly significant ( p = 1.45*10 −29 , p = 3.83*10 −26 , p = 4.66*10 −11 , respectively).

We found a highly significant replication (mean R 2 = 0.07; P = 1.5 × 10 −29 ), explaining 41% of in-sample cross-validation R 2 (Supplementary Figure 3 ), which is consistent with previous out-of-sample estimates 24 , 25 .

Compared with the control group, combined dcEF + RL stimulation produced a highly significant increase in neurite length ( P = 2.1 × 10−29, η 2 = 0.54).

One example was IL‐6, with a cis ‐pQTL (rs79103996) that was highly significant in CSF ( P = 2.9 × 10 −29 ) but had no association in plasma ( P = 0.38), suggesting relevant tissue‐specificity of IL‐6 regulation.