“highly significant”

S6 ) and highly significant ( p = 5.1 × 10 −34 , Fischer’s exact test).

A second, highly significant set of associated variants in 1q32.2 was defined by the lead SNP rs570516915 ( P = 5.25 × 10 –34 , OR = 8.65, Fig. 2b ).

After using k-means clustering to assign individuals to two different groups according to their coordinates in the PCoA, a highly significant association ( P = 5.41 × 10 -34 ) between the k-means assignments (n cluster1 = 531, n cluster2 = 118) and breeding program subgroups (n subgroup1 = 352, n subgroup2 = 297) was found.

This represented a highly significant difference (two-way analysis of variance (ANOVA) with factors young/adult stage, and individual monkey; F 1,304 =189.7 for main effect of stage, P =7.2 × 10 −34 ).

The results revealed an important positive correlation with a coefficient of determination R 2 = 0.72 and a highly significant p-value (p = 7.51 × 10 −34 ), indicating a robust linear relationship.

Other highly significant pathways included skeletal system development ( p = 8.431 × 10 −34 ), cartilage development ( p = 8.904 × 10 −34 ), and ossification ( p = 1.231 × 10 −33 ).

This analysis revealed a novel variant, rs148726219, located on chromosome 19q13.32 (>500 kb from APOE ) which showed highly significant association with AD in DF3 (p = 8.9e-34, OR = 2.5) and had further increased significance in the later release DF6 (p = 2.7e-54).

All canonical correlations were highly significant: schizophrenia: r = 0.07, P = 8.98 × 10 −34 ; bipolar disorder: r = 0.07, P = 1.53 × 10 −35 ; autism: r = 0.06, P = 7.87 × 10 −24 ; attention-deficit/hyperactivity disorder: r = 0.08, P = 7.84 × 10 −44 ; left-handedness: r = 0.07, P = 1.74 × 10 −31 ; Alzheimer’s disease: r = 0.07, P = 4.14 × 10 −33 ; amyotrophic lateral sclerosis: r = 0.06, P = 1.29 × 10 −25 ; epilepsy: r = 0.05, P = 1.49 × 10 −20 .

The variants (rs16847897 and rs10936599) of telomerase complex showed highly significant association ( p- value = 9.4E-34, OR = 5.04 (3.88–6.55) at 95%CI) with T2D.

Support Vector Machines achieved 84.06% accuracy and 93.56% sensitivity, with highly significant group differences across all features ( p < 10 −33 ; Cohen's | d | = 0.87–1.51).

Notably, there is highly significant overlap ( P < 1 × 10 −33 ) between the WHSC1 target genes identified and the differentially expressed genes in KMS-11/Cfz (86 out of 887; FC ≥ 1.4) and KMS-34/Cfz (69 out of 888 genes, FC ≥ 1.5).

cholerae and rotavirus was highly significant (p = 1.12 × 10 –33 ).

Further analysis of the differentially methylated probes in all primary human keratinocytes from 13 different donors also showed a moderate, but robust and highly significant ( p = 1.4 × 10 −33 , t -test) reduction of DNA methylation in the DHM-treated cells ( Figure 2B ).

This represents a highly significant overlap (Fisher Exact Test p-value = 1.45E-33).

PALD1 (paladin) on chromosome 10 is highly significant ( p < 1.53e‐33) as it stands out from the other genes in Figures 3 , 4 .

These differences were highly significant by Mann–Whitney U tests (P ≈ 1.7 × 10 −33 for SOX2_Gradient, 9.4 × 10 −24 for SOX2_Tile_Gini, 3.2 × 10 −25 for CD44_HScore, and 2.4 × 10 −12 for Prague M).

1c, d ) is highly significant ( P = 3.06 × 10 −33 ) and cannot be explained by a random process of microbial recruitment from the same starting soil community.

A log-rank test revealed highly significant distinction across the clusters in terms of survival probabilities ( p = 3.7 × 10 −33 ), which was clearly better than that observed in the standard clustering ( p = 7.4 × 10 −10 ; Figure F in S2 File ).

We found that HOXC8-ssr , HOXC8-3end and HOXC11 all showed highly significant significant linkage to Crest ( P = 5.5×10 −33 ) with no recombination event detected ( Fig. 2 , Table S3 and S4 ).

For example, the probability of finding a lower co-occurrence than observed for the GO terms “RNA processing” (GO:0006396) and “signaling” (GO:0023052) is very low in human (therefore highly significant), as indicated by their AP , p = 7.5e-33 (Figure 2 ).

Specifically, we first applied Cochran's Q test across all three models, which revealed a highly significant global difference ( Q = 147.72, p = 8.36 × 10 −33 ).

Strikingly, ontology analysis resulted in a highly significant enrichment for genes involved in the regulation of insulin transport (hypergeometric test p-value < 10e-33).

A highly significant positive correlation ( p value < 1e−32; R 2 = 0.59) was observed between the total number of additional HGs formed within a Pango lineage and the total number of genomes assigned to that lineage.

A GEE analysis, with robust SEs, adjusted for age, sex, cognitive state, APOE‐ε4 status, years of education, and recruitment site, indicated a highly significant overall group effect on BAGs ( χ 2 (4) = 156.07, p < 10 − 32 ).

This difference was highly significant (t-test, p < 10 −32 ).