Barely Significant
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may be significant

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In the literature

Those patients with significant hemodynamic changes may present congestive heart failure or in the long-term may develop irreversible changes in pulmonary vascularity leading to pulmonary hypertension.[ 9 ] There may be significant co-morbidity including pulmonary edema and bleeding, bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH) bleeding, necrotizing enterocolitis (NEC), feeding intolerance and retinopathy of prematurity (ROP).[ 9 ] However, in recent articles the effect of ductus closure on mortality and
Third, it is obvious that the dose of the ingestion, duration between the ingestion and presentation to the ED, comorbidities, coingestions, medical history, severity of the disease process, quality of the treatment, level of the hospital, and expertise of the providers may be significant confounders, therefore, all conclusions should be corrected for those variables.
As such, their contributions would be unlikely to be perturbed by the solvent-mediated recrystallization. This observation is in noteworthy contrast to vibrational SFG measurements of the benzene/air interface, in which calculations and measurements suggest quadrupole effects may be significant. 10 , 11 Furthermore, SHG arising from trace impurities can similarly be excluded, as they would be present in equal quantities before and after exposure to solvent vapor.
This may be significant because enhanced or premature chondrocyte cell death may trigger subsequent events that accelerate degradation of cartilage.( 17 ) It was shown in articular chondrocytes that TNF-α-induced apoptosis was associated with increased expression of genes related to matrix degradation such as MMP and macr
Despite the advantages, nMS is not used to the extent of the more common biophysical methods, including those where there may be significant challenges such as X-ray crystallography, that requires proteins suitable for crystallisation, or NMR, where proteins are commonly isotopically labelled and high fragment stock concentrations are needed, that can frequently meet with insufficient solubility leaving many fragments unsuitable.