“may be significant”

The use of these agents is discouraged in patients suffering from liver, renal, or heart disease, and in those receiving medications with which there may be significant drug–drug interactions [ 27 ].

It is necessary to note that the chi-square test is sensitive to the size of the sample, and it may be significant when the actual difference between the observed model and the implied model covariance is small. 3.

The present study is confined to the understanding of in vitro enzyme inhibitory activity of COX-1 and COX-2 and the production of PGE2; thence, it may be significant to understand the effect of ACEOs at the transcriptional activation level involving the NF- κ B, C/EBP, CREB, and c-Jun proteins. 3.7.

There is, at present, no evidence to determine the relative importance of the tubule system and of the surface membrane of the microvilli in the secretion of hydrochloric acid. However, it may be significant that the tubules are more closely associated with the mitochondria than are the microvilli.

Although their age distribution is similar to that of express terminal sorters, there may be significant differences in terms of work experience, physiological fitness, and lifestyle habits.

11 , 38 There may be significant underreporting of cases in countries where CAM is not actively monitored, but overreporting is also a consideration, as an Australian chart review found that 13 of 20 (65%) cases did not meet the ‘Ronaldson criteria’ for a clinical diagnosis of CAM. 39 Here, although elevated troponin was prese

There may be significant differences between youth who have not disclosed their orientation versus those who have in terms of family functioning, drug use, sexual risk behavior, and depressive symptoms.

Consequently, we considered the possibility that there may be significant mass effect in the brainstem owing to the fourth ventricle hematoma.

Thus, the effect of accommodating elastic bands on BSQ may be significant but restrictive.

Thus, the progressive accumulation of uremic metabolites, especially ones that may be poorly filtered by conventional dialysis membranes, may be significant contributors to the progressive decline of mitochondrial health observed in patients with CKD.

Although these data suggest that access to dental care has not been notably limited, the real impact of a pandemic on oral health may be significant.

Therefore, early WD activation may be significant in nerve degeneration and regeneration. 15 , 16 , 17 , 18 , 19 Using bioinformatics technology, we found that CLDN 14 and CLDN 15 are vital to the signal network regulating sciatic nerve injury regeneration.

The processes observed by the Williams group may be significant for ion formation in previously disclosed ion sources, including ESI and ambient ion sources.

Self- direction is an important aspect of clinical attachments, as there may be significant time spent apart from the team.

Since the number of people in the vaccinated group was significantly smaller than that in the unvaccinated group, there may be significant differences in other key characteristics, making the comparison results between the two groups inaccurate or subject to selection bias.

Thus, like in larval transmission, it may be significant for YFV transmission or persistence in enzootic foci in sylvan environments.

The potential efficacy of low doses (25 and 50 ng/mL) in reducing factors of the NF-κB and MAPK pathways, similar to COX-2 and iNOS, may be significant for inflammation treatment.

Other studies have suggested that male sex and cholesterol levels may be significant risk factors for high vascular calcification in young adults ( 20 - 22 ), while others have proposed that psychological factors and emotional stresses may also play a role ( 23 , 24 ).

In general, the two factors of publication date and sample size may be significant and powerful factors in reported RCT quality, which should be well researched in future RCTs.

Lateral diffusion and vesicle tumbling are not expected to influence the line shape because of the large size and low curvature of MLVs, 19 , 23 but if FBTA disrupts the lipid bilayer and promotes the formation of smaller vesicles and/or non-bilayer structures then contributions of these modes of motion may be significant.

Because other iAs exposure routes, particularly diet, may be significant when concentrations of iAs in drinking water are low ( Lindberg et al. 2006 ), we performed analyses that excluded those with a sum of iAs metabolites in urine < 2.5 μg/L (in line with Lindberg et al. 2006 ).

It may be significant that ME7‐associated increases in IBA‐1, cathepsin D, and CD68 expression in white matter (cc and internal capsule) were mitigated in IFNAR1 −/− mice.

[ 4 , 5 ] These symptoms, regarded as components of dry eye, range in severity, but the effects on quality of life may be significant.

As in resolvase there may be significant conformation changes that occur with activation of recombination ( 34 , 37 ).

The 2 B 2 g state of IsdI–heme–CN exhibits no intense peaks downfield of 12 ppm, whereas the 2 E g state of rHO–heme–CN has several resonances in this region, including two assigned to heme methyl groups. Thus, the downfield hyperfine-shifted resonances of MhuD–heme–CN suggest that there may be significant population of a 2 E g state in MhuD–heme–CN at 25 °C.