Barely Significant
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may be significant

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In the literature

Currently, no studies have investigated the dose-dependent effects or the impact of exposure duration to halogenated anesthetics in clinical settings, although evidence from animal and in vitro research suggests that these factors may be significant. 10 , 50 , 51 , 52 While Beck-Schimmer et al., 35 Lisnyy et al., 33 Nguyen et al., 10 and Koraki et al. 9 performed pharmacological preconditioning for 30 minutes, Rodríguez et al. 19 conducted preconditioning for 20 minutes.
It should be noted that a trend lower than the effect size may be significant in a single data set (Sb, As), but the chance to detect this trend in all possible trials, with samples of the same size and variance, from the same population, would be less than 80%, i.e., the statistical power will be less than 80%.
The Cochrane Collaboration and their review on the same aspect suggest a 2-year timeline before updating an SRMA.[ 2 ] However, there may be significant limitations with this fixed timeline, particularly with much original research being published on fascinating and controversial topics that have clinical importance in improving patient care.[ 2 ] Moreover, it usually takes a median of 16 (interquartile range: 10–24) months for an SRMA to get published from conception and design.[ 3 ] It is feasible for different research groups around the globe to plan an SRMA on the same topic within overlapping time.