However, as suggested by others the role of Tau phosphorylation in GSS [ 19 ] and in human prion diseases initiated by infection (iCJD) may be significant and contrast with its role in human prion diseases where an infectious source is yet to be identified (sCJD).
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In the literature
These factors may be significant in each context when they are in their initial stages, but they become less significant or useful as they become normative.
Clinical knowledge of these syndromes and their association with GBC and other neoplastic diseases may be significant concerning early detection of the disease.
Such flow in normal brains is not significant compared to that from high flow rate infusions, but it may be significant in either chronic infusions or, more pertinently, in brains with pathological states of disrupted blood–brain barrier (BBB), where there are endogenous sources of fluid as well as serum proteins from the vasculature that alter the oncotic pressure in the interstitium [ 43 ].
A key consequence is that our cases were predominantly Western examples of menthol’s use and there may be significant other uses we were unable to capture.
Spirometry is required to make the diagnosis, however there may be significant lung pathology (e.g., emphysema) in the absence of airflow limitation that needs further evaluation.
The results of subgroup analyses and meta-regression analyses suggested that the HR estimation may be significant variable associated with heterogeneity among studies.
These psychological mechanisms may be significant enough that they are able to surpass declines in learning and memory conferred by volatile compounds of plant aromas.
Taken with the interactome observed for the 9 mRNA binding/splicing factors, there may be significant opportunity for overlap between these factors and other splicing factors in contributing to regulation of BMP4-dependent transcription.
According to our research, a pre-operative measurement of <3 mm for RBH may be significant for figuring out what amount of bone gain can be obtained but is not always indicative of implant failure.
Therefore, it is speculated that there may be significant differences in the color development ability of different monosaccharides after condensation with phenol.
On the other hand, because many significance tests were conducted, some p -values may be significant by chance assuming that the distributions are the same across the High-to-Low and Low-to-High versions.
While this additional energy may be small (of the order of 1% of the total substorm energy budget), it may be significant, particularly in controlling substorm onset.
We note that these values are averaged and do not reflect interpatient variations, which may be significant for certain parameter configurations.
These findings may be significant for the treatment of persistent M. abscessus infections.
Remarkably, different levels and combinations of inflammatory signaling molecules can elicit opposing responses, suggesting that context may be significant.
While the precise implications of the nature of host-environment microbiome sharing in captivity compared to that in the wild are unknown, an increased incidence of disease in urbanized humans as well as in captive animals compared to their wild counterparts suggests that the consequences may be significant ( 15 ).
From recent meta-analyses, however, there is growing evidence, that although pRT and TLM are equivalent in terms of local control (LC), there may be significant differences in overall survival (OS) and laryngeal preservation (LP) [ 18 , 19 , 20 , 21 ].
Our findings are important, because understanding specific relationships between FMS and PA may be significant for improving specific skills or a specific PA intensity.
It may be significant that the type of radiation used in this study, moderate energy X-rays, is quite similar to the type of low energy, and largely unfiltered, fluoroscopy X-rays used here 20 , albeit for therapeutic rather than diagnostic purposes, and contrasts with the rather higher energy radiation to which nuclear
Studies such as the one presented herein may be significant to establish such knowledge and practices, along with the characterization of those demographic and agroculinary factors that contribute to the promotion of local WFP production, consumption and exchange, in the frame of a revitalisation of mountains, meadows, and in general, rural areas.
These lesions may bleed intermittently, which may be significant enough to be noticed in the form of haemetemesis or melaena, but eventually lead to iron depletion and iron deficiency anaemia.
(2009) found that probiotic administration reduced time of resolution of diarrhoea by 2.5 days, which may be significant to many owners.
It is also important to recognize that there may be significant age and sex stratification in crop‐foraging patterns (Schweitzer et al., 2017 ; Strum, 2010 ) so the data collected from the single study baboon, an adult female, may not be wholly representative of the entire group.
A number of studies have previously estimated the time to perform remote and in-person device checks, yielding a wide range of time estimates, suggesting that there may be significant clinic-to-clinic variability [ 14 , 31 - 33 ].