Barely Significant
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moderately significant

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P<0.11p>0.11

Listed by Hankins, posted since · Hankins (2013) · Otte et al. (2022)

In the literature

64 The UKBB demonstrates only 1 moderately significant phenotypic association for pLoF variants (mean corpuscular volume) ( https://app.genebass.org/gene/ENSG00000108055 ). 65 Intriguingly, in an analysis of >31,000 individuals with neurodevelopmental phenotypes and their family members, de novo variants in SMC3 were found to be associated with developmental delay (false discovery rate = 3.46E−7), although driven mostly by missense variants. 66 The lack of phenotypic associations with SMC3 pLoF variants in large cohorts could be because of a lack of true association and/or lack of power owing to the rarity of these variants.
CONCLUSIONS Nontubercular respiratory disease patients suffer from poor periodontal health status indicated by greater mean PI (moderately significant) and significantly higher mean CALs than PD patients representing a past episode of periodontitis that had caused loss of CALs and consequently gingival recession in such patients.
Thus, for Active genes we found: strongly significant negative CC for resistant nucleosomal sites around TSS [−120; +80] for tissue-specific and modest; moderate negative CC for sensitive nucleosomal sites for tissue-specific [−30; +50] and modest [+10; +70]; strongly significant positive CC downstream TSS [+70; +200] for tissue-specific and modest; moderately significant positive CC for sensitive nucleosomal sites upstream TSS in tissue-specific [−210; −180]) and modest [−160; −150].
Values 0.90 < pbe < 0.94 or 0.06 < pbe < 0.10 may be considered moderately significant, 0.95 < pbe < 0.99 or 0.01 < pbe < 0.05 may be considered significant, and pbe > 0.99 or < 0.01 highly significant. 2-to-1 Matched-Pair Analysis To further evaluate the impact of PK-guided Bu dosing, we compared the outcomes of patients in the fixed-dose Bu group whose natural metabolic capacity for busulfan yielded an average daily Bu AUC of 6,000 μM-min (±10%) when they received 130 mg/m 2 with patients in the PK-guided Bu dose group using a matched-pair analysis.