Smad5 appears to participate in these signaling events, but its impact is small and of borderline significance in the current system.
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“of borderline significance”
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However, in multivariate analysis, SBRT dose (p = 0.0072) was the most significant factor, while Child-Pugh stage of borderline significance.
Proportionally, more women who became pregnant consumed 14 units or less of alcohol a week compared with those who did not become pregnant (85% v 80%), and this difference was of borderline significance.
However, this difference was significant in only 3 studies and was of borderline significance in 3 of 14 studies where GRS was measured.
9 , 10 Two case studies 1 , 2 reported that nulliparous women younger than 45 years of age with breast cancer did not show a left-sided predominance, and a large population-based study reported that left-sided predominance increased with age at diagnosis and was of borderline significance in women younger than 55 years of age. 8 , 9 In the present analysis, age and ethnicity were unrelated to breast cancer laterality.
For three genes in the data set, KRT5, KRT6A, KRT6B , there was a significant association between gene expression and inferior prognosis unique to young women (with overexpression of EGFR of borderline significance).
However, OGG1 variants have recently been demonstrated to be significantly associated with a multiple adenoma phenotype [ 42 ] and the development of sporadic CRC [ 43 ], although the latter association was of borderline significance and should be further investigated [ 43 ].
Besides aggressive fluid replacement, AKI was identified as a positive predictor of prolonged hospitalization while male sex was of borderline significance (Table S4, Supplemental Digital Content 1, http://links.lww.com/MPA/B397 ).
An exception is the association with the handling of heavy objects, which turned out to be of borderline significance.
Given that the P value of DFS multivariate analysis is of borderline significance, the association should be interpreted with caution, and validation in a larger, multicenter cohort is needed to confirm this finding. 3.2.
This was not entirely unprecedented; a large clinical trial comparing IB with placebo in mild COPD noted increased cardiovascular morbidity and mortality of borderline significance in the group assigned IB, and a particularly suggestive increase in the incidence of SVT ( Anthonisen et al 2002 ).
Restricted cubic spline analyses identified distinct dose–response associations between dietary patterns and sarcopenia risk: (1) Dietary Pattern 1 did not demonstrate a significant linear association with sarcopenia risk (P-overall = 0.180), the RCS analysis indicated a non-linear pattern of borderline significance (P-nonlinearity = 0.089).
On comparing the PAPR systems pairwise, the difference between PAPR B and PAPR C was of borderline significance, with PAPR C producing higher log reductions than PAPR B, and PAPR A between the other two.
In addition, two new mitotic interactions were found in our analysis: Rev7 showed interaction with Rad54 and with Rad57 ( Table 1 and Figure 4A ; the Rev7 - Rad54 interaction, however, was only of borderline significance in our statistical analysis).
In addition, in post-hoc analyses, smoking tobacco was of borderline significance for being an effect modifier for total mortality, and since smoking tobacco has decreased since the study was done, the results even in the narrow VA population targeted earlier could have been different had the study been done today ( 7 ).
As these results were only of borderline significance and not consistent over the two time points (morning, afternoon), we believe that the observed associations are due to chance or multiple testing.
Accordingly, both nuclear and cytoplasmic HJURP immunopositivity were correlated with worse DFS (log-rank test, p = 0.071 for nuclear, p = 0.019 for cytoplasmic Figure 5 ), the former association being of borderline significance.
Relation of heart failure was of borderline significance.
Those who had made at least 1 quit attempt (OR 0.73, 95% CI 0.54-1.00, P =.05) were also less likely to access the separation exercises, although this was of borderline significance.
Both manual parental social class and overcrowding in the household at birth were significantly related to reporting a cancer before 50 y, and mother’s education was of borderline significance.
The results of the first model were substantially confirmed: an increase in BAC was significantly associated with an increase in reaction time; and the increase of BAC between the entry and the exit from the recreational site caused a lower augment of reaction time among the males, who also showed a lower reaction time than females (although of borderline significance).
Transfer of 2 embryos was a significant factor for occurrence of abnormal placentation and spontaneous cycle ET (i.e., ET without any stimulation) was of borderline significance ( P value being between 0.050 and 0.100) for absence of abnormal placentation.
Blood lead was of borderline significance to cigarette smoking.
Furthermore, we observed a strong positive enrichment trend for pathways related to DNA synthesis and metabolism, including “Regulation of DNA Replication” (NES = 2.64), “Glycine, Serine and Threonine Metabolism” (NES = 2.64), and “Carbon Metabolism” (NES = 2.92), although the adjusted P -values for these pathways were of borderline significance (Fig. 7 G–I).
In multivariate analysis, the relationship between NT-proBNP and LAVI remains significant, while the relationship between NT-proBNP and LV EF is of borderline significance.