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showed a trend

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showed a trendP = 0.051.0× alpha
Although the mean median pitch remained within normal range with an overall non-significant change (−3.8, NS), analysis by gender showed a trend for statistical significance ( P = 0.05) on the impact on median pitch (i.e. the fundamental frequency): while it decreased among 80% of the female patients [from 203 ± 38 to 189 ± 31 Hz (normal range: 140–220 Hz), n = 19], it was almost unchanged in the male patients [from 135.2 ± 23 to 134.5 ± 26 Hz (normal range: 85–180 Hz), n = 29] ( Supplementary Fig. 1 ).
did not reach statistical significanceP > 0.051.0× alphaplainly factual
showed a trendP > 0.051.0× alpha
Regarding fibrosis indicators, although PCSK9i use showed a trend toward improvement in Δ APRI (β = −0.021) and Δ FIB-4 (β = −0.19), these associations did not reach statistical significance in the adjusted model ( P > 0.05).
showed a trendP =0.051.0× alpha
These benefits persisted during follow-up: headache days (standardized mean difference [SMD], −0.70; P <0.00001), intensity (SMD, −1.11; P =0.008), duration (SMD, −1.83; P =0.003), and analgesic use (SMD, −0.60; P =0.007) remained reduced; headache frequency showed a trend toward reduction (SMD, −0.47; P =0.05).
showed a trendp > 0.051.0× alpha
At the beginning of the trial, males showed a trend toward choosing the EO-treated arm, although no statistical differences were found (χ 2 = 2.46; p > 0.05), whereas females showed a preference for the EO-treated arm (χ 2 = 4.17; p = 0.04) ( Table 2 ), but no significant differences were observed at the end of the trial (χ 2 =3.11; p > 0.05).
showed a trendP < 0.051.0× alpha
Although there was no statistically significant difference in postoperative hospitalization between the 2 groups, the mEMR-C group showed a trend toward reducing postoperative length of stay compared with the ESD group (without adjustment: P < 0.05; with adjustment: P = 0.075).