In a phase II, randomized, double-blind, placebo-controlled study, vandetanib showed a trend of improvement in PFS and OS for advanced HCC, but there was no statistically significant difference compared to the placebo arm.
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In the literature
Stöhr and colleagues 14 performed a univariate analysis that showed a trend toward improved outcomes in patients with acute respiratory distress syndrome supported with V-AV ECMO compared with isolated VA and VV ECMO.
Our analysis also showed a trend towards a reduction in social inequality.
At d 21, the PCoA plot showed that the ileal microbial community of the SPM group showed a trend of separation with the CTL and SPH groups.
When subdivided into subtypes, the increase showed a trend in significance in both type IIIA and IIIB patients.
The addition of the AMPK inhibitor, Compound C (10 μM), to exogenous Aβ 42 monomers showed a trend toward the reduction of lactate release that, however, did not reach significance.
The contents of all constituents in leaf showed a trend of increase-decrease-increase-decrease with the plant growing.
Concerning parental alcohol use, students who reported at least one episode of maternal drunkenness showed a trend to be more likely to belong to the high drug use/high problems class than to the low drug use/low problems class (aOR = 2.87, 95%CI = 0.99; 8.32 and aOR = 4.78, 95%CI = 1.33; 17.20, MI and FIML, respectively).
The oxaliplatin-based regimen for patients with neoadjuvant chemotherapy showed a trend toward improving recurrence-free survival ( Figure 3B ); however, this result did not reach statistical significance when compared to the nonoxaliplatin-based regimen (53.3 versus 42.8 months, p=0.14, respectively).
Discussion This exploratory study showed a trend for synaptic loss measured in vivo with SV2A-PET in the anterior parahippocampal gyrus of our sample of bvFTD patients, while atrophy was predominant in the ventromedial prefrontal cortex.
We found that ICIs in combination with chemotherapy showed a trend of superior efficacy along with acceptable treatment response compared with monotherapy involving ICIs.
The NMDS analysis depicted that the HF group was clearly separated from the CON group, and the YCWLP group was located in the middle of them and showed a trend away from the HF group and close to the CON group ( Supplementary Figure S4D ).
A scatter-plot showed a trend towards higher haematocrit-haemoglobin deviations as haemoglobin increased.
However, HFD significantly aggravated the motor performance in the cylinder test and showed a trend toward higher rotations in amphetamine-induced rotations, indicating an imbalance of dopamine release between the lesioned and intact side of the brain [ 34 ].
Furthermore, the NO 2 and PM 10 concentrations at Level III showed a trend of decreasing again.
The time to first post-discontinuation chemotherapy showed a trend for improvement in the abemaciclib group compared with the placebo control, with median TTC 52.3 versus 26.8 months, respectively (HR: 0.651; 95% CI: 0.353–1.198) and median CFS 50.2 versus 26.8 months, respectively (HR: 0.609; 95% CI: 0.344–1.076; Online Resource 5).
Both IM and rhACE2 patch group showed a trend of better systolic function preservation compared to PLLA group, reflected by left ventricular ejection fraction (PLLA: 27 ± 11%, IM: 31 ± 3%, PLLA-HA/ACE2: 31 ± 14%) and fractional shortening (PLLA: 10 ± 8%, IM: 15 ± 2%, PLLA-HA/ACE2: 15 ± 7%) (Fig. 6c, d ).
Furthermore, in Arabidopsis , cis -(+)-12-oxo phytodienoic acid (OPDA) and 10-oxo dinor -phytodienoic acid ( dn )-OPDA were not significantly affected and even showed a trend of increase at warm temperature like the expression of the regulatory enzymes (Supplementary Fig. 15a, b ).
reported that the number of coexisting asymptomatic ICAS showed a trend toward a higher recurrence rate (Arenillas et al., 2001 ).
The 1.9 μg HA/AS03 B formulation showed a trend for the highest cross-reactivity against 3 heterologous strains versus other formulations (Table 2 ).
This curve showed a trend toward better overall survival (OS) in patients with blood glucose levels of <5.53 mmol/L than in patients with blood glucose levels ranging from 5.53 to 7.27 mmol/L (hazard ratio [HR], 6.34; 95% CI, 1.45–27.71) and ≥7.27 mmol/L (HR, 19.37; 95% CI, 4.68–80.17).
Social capital showed a trend towards a positive correlation with DALY-Dem, but this was not significant after correction for multiple comparisons (r = 0.29, p = 0.235).
PLOS ONE showed a trend of decreasing numbers of articles with supplementary Excel gene lists and number of affected articles but the proportion of affected articles was relatively flat over this time.
For patients who were treated with fewer prior regimens showed a trend towards longer survival.
Although not significant, complementing p42 expressing cells with RNase L showed a trend in reducing viral RNA and titer ( Figure 3—figure supplement 1D, E and F ).