“showed a trend”

The same three beneficial alleles showed a trend toward higher pre-treatment sHLA-G plasma levels, supporting a functional role for polymorphisms in protein secretion.

Moreover, while not all genes were significantly upregulated in the high D-dimer group, 10 out of 12 showed a trend toward an increased gene expression as D-dimer concentration increased (Fig. 6e ).

With respect to the studies focused on galectin-9 expression tissue, Punt et al reported that presence of galectin-9 showed a trend toward improved survival and Beyer et al reported that high expression of galectin-9 was correlated with better prognosis, so these studies are not contradictory. 2 , 3 But, the results of serum concentration of galectin-9 obtained in our study showed that serum concentration increases in advanced FIGO stages and it is not related with the level of expression in the tumor tissue; these results suggest that galectin-9 could be playing different roles in the tumor cells and in the serum.

CD8+CD28+T cells showed a trend of decrease with aging after ART in our results, which is in line with research showing that CD8+CD28−T cells are often regarded as symbols of short telomere length, promoting pro-inflammatory molecules production, and reducing proliferation signal [ 26 , 27 ].

Interestingly, three proteins with q < 0.05 (SAM analysis) were downregulated, and most of the remaining proteins also showed a trend of downregulation although their q values >0.05 ( supplemental Table S9 ).

After co-culture with OA-FLS, M2 Mφs showed a trend of transition to the M1 phenotype, with decreased polarization markers of M2 (CD206, ARG1).

Moreover, treatment of vitamin B2 and vitamin C significantly reduced the number of Proteobacteria , and showed a trend to increase the number of Firmicutes and decrease the number of Bacteroidetes ( 70 ).

Despite the positive results, the hybrid membrane-ionic liquid showed a trend of mass losses at temperatures slightly below the temperature of decomposition (Td).

The ML index of an undesired output from 2009 to 2019 was greater than one in most years, indicating that tourism eco-efficiency in Inner Mongolia showed a trend of optimization.

LSR showed a trend of positive association with KGR-F, although the correlation was not significant ( r = 0.6, p = 0.07) ( Supplementary Material 1 ).

Although the COVID pandemic restricted the follow-up, this research conducted in a naturalistic service setting, indicated that the group receiving a combined NEAR + SCIT approach showed a trend toward improved functioning.

Likewise, PRS of LGE + segments showed a trend towards higher contractility (SMD = − 0.12; 95% CI − 0.08 to 0.31), whereas LGE− segments tended towards lower contractility (SMD = − 0.19; 95% CI = − 0.29 to − 0.08).

Furthermore, most studies showed a trend toward a shorter median survival time in the PC + LM group and the median OS reported was 29 months.

Notably, the phosphorylation level of Akt showed a trend of first rising and then falling, with a peak at 8 h at all tested extracellular vesicle concentration.

The average annual yield of the wheat-maize rotation system showed a trend of increasing and then decreasing as the manure substitution ratio increased.

The germination index of the wheat seeds treated with the base extract showed a trend of decreasing and then increasing, indicating that some toxic substances were produced by the heap during the aging process.

We also observed that, in addition to the corpus callosum, some specific white matter tracts such as the superior longitudinal tract, inferior longitudinal tract, and inferior frontal-occipital tract also showed a trend of decreased FA and increased MD, AD, and RD in the NDD-CKD and DD-CKD groups, and the extent of lesions was also more pronounced in the DD-CKD group.

The SOD activity, POD activity, proline content, and SP of ‘Yu Hong’ leaves showed a trend of increasing and then decreasing with the extension of treatment time, MDA content was gradually increasing, and the REC showed a trend of increasing and then stabilizing under heat stress.

18 showed a trend that higher PEWS during transport were associated with PICU transfers, although not statistically significant.

The median disease duration from diagnosis until initiation of biological treatment did not differ over the 10 years in UC patients, but showed a trend towards shorter time to treatment in CD patients ( Table S1 ).

The distribution of values showed a trend for increased synchronization with cellular density, but not a clear threshold of transition between island groups as in the case of activity rate ( Figure 4I ).

Albeit statistically non-significant, or subgroup analysis showed a trend that studies that recruited dialysis patients with a high proportion of CAD (≥ 50%) or those who aged more than 65 years had a lower mortality risk if the patients received NDBBs compared with those being given DBBs.

6 However, subgroup analyses from some trials showed a trend toward benefit in patients with triglycerides ≥200 mg/dL (≥2.3 mmol/L) and HDL-C ≤ 40 mg/dL (≤1.0 mmol/L) who received fibrates. 82 – 85 Patients with severely elevated triglycerides (>500 mg/dL [>5.7 mmol/L]) are at risk of pancreatitis.

[ 18 ] Studies showed a trend toward a higher frequency of anosognosia after right brain lesions, while the presence of this symptoms after left brain damage ranged about 49% to 86%.

Unresectable residual disease showed a trend toward inferior survival, both in terms of PFS and OS.