Assessment of the Mutation Profile of Tonsillar Squamous Cell Carcinomas Using Targeted Next-Generation Sequencing.

25 months; p = 0.049); however, the difference was not statistically significant and showed only borderline significance in the univariate analysis carried out using the Cox proportional hazard regression model ( p = 0.058).

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Although the significance of discordant cancers is controversial, patients with discordant cases demonstrate a borderline significant trend toward survival differences compared to those with concordant cases, which may be a potential therapeutic strategy for discrepant tonsil cancers with SMARCB1 mutation [ 47 , 48 , 49 ].

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Older age ( p = 0.020, HR = 3.565, 95% CI = 1.221–10.412) and advanced stage ( p = 0.006, HR = 5.246, 95% CI = 1.596–17.235) were independent predictors of shorter OS in patients with TSCC; however, RTK pathway mutations did not reach statistical significance in the multivariate analysis.

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RTK pathway mutations failed to reach statistical significance in the multivariate analysis.

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8.4%, respectively) showed a trend that was similar to our results, whereas HRAS (0% vs. 5.7%, respectively), AKT1 (1.4% vs. 0.4%, respectively), and FLT3 (0% vs. 0%, respectively) showed lower expression.

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