CD28/PD1 co-expression: dual impact on CD8⁺ T cells in peripheral blood and tumor tissue, and its significance in NSCLC patients' survival and ICB response.

1 D), while TIGIT showed a strong trend of higher expression in the absence of CD28 (Table S 3 ).

also in 5,725 other papers

GSEA reveals a clear trend for a higher expression of an “exhausted” transcriptional signature, while “pre-exhaustion” genes were more correlated with CD28 + cells.

also in 19,460 other papers

KLRG1, a marker of both terminal differentiation [ 29 ] and context-dependent T-cell activation [ 28 ] showed a trend for higher expression in CD28 + T cells (Fig. 1 E).

also in 53,322 other papers

While the observed differences did not reach statistical significance, there was a discernible trend in Ag-specific CD28 − T-cell clones towards exhibiting a higher expression of an "exhausted" transcriptional signature, while "pre-exhaustion" genes displayed a stronger correlation with CD28 + cells (Fig.

also in 111,027 other papers