The Status of SOX2 Expression in Gastric Cancers with Induction of CDX2 Defines Groups with Different Genomic Landscapes.

Mutations in APC were also frequent in gastric cancers with CDX2 induction and SOX2 suppression (16.2% of cases), and the difference in prevalence compared with SOX2-maintained-expression cancers approached significance (Fisher’s exact test with p = 0.06).

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A comparison restricted in CIN cancers from the two groups disclosed only minor differences that did not reach statistical significance ( Figure 2 B).

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In contrast to prominent mutations, copy number alterations showed a trend for higher prevalence in the group with SOX2-maintained expression ( Figure 4 ).

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On the other hand, TP53 mutations and amplifications in MYC , ERBB2 , and CCNE1 were more common in the group with a maintained expression of SOX2, approaching significance for MYC .

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