Combined Effects of Environmental and Lifestyle Exposures on Liver Health: The Mediating Role of Allostatic Load.

Finally, for FLI ( Table 11 ), AL was highly significant and positively associated ( p < 0.001) while alcohol consumption was inversely associated with FLI.

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CDEs at different quantiles (10%, 50%, 75%): The controlled direct effect shows a slight downward trend and a negative trend across the AL quantiles for both age groups.

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Alcohol did not reach statistical significance for most liver enzymes but was negatively associated with FLI, which contradicts conventional assumptions.

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Furthermore, AL showed a near-significant association with ALP and total bilirubin, suggesting potential links to bile duct stress or hepatic excretory function.

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Left Plot: 30th percentile of Age (mid-age group) Effect Estimates: The effect estimates show a decreasing trend as the exposure quantiles increase, moving from positive and then falling to zero as it approaches the mid quantile, and slightly increasing as the quantiles increase.

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On the other hand, for ALP, both smoking ( p < 0.01) and age ( p < 0.01) were positively associated, while alcohol consumption and AL were not statistically significant but approached significance.

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For ALT, lead showed a marginally significant positive association, suggesting a potential link between lead exposure and liver stress.

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