Evaluating murine double minute 2 status as a stratification tool for risk-adapted management in plasma cell neoplasms.

Of particular importance, a strong, positive, and highly significant correlation persisted between IMWG response categories at 12 weeks and 24 weeks (Kendall’s tau-b = 0.627, P < 0.001; Spearman’s P = 0.678, P < 0.001), demonstrating that early treatment responses strongly predicted subsequent outcomes throughout the course of therapy.

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The likelihood ratio test approached significance [ χ 2 (2) = 6.140, P = 0.046], while the linear-by-linear association test did not indicate a significant trend [ χ 2 (1) = 0.473, P = 0.492].

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Among cases for which there was accessible CD56 IHC ( n = 60), CD56-negative cases showed a trend towards greater MDM2 positivity (42% vs 23%, P = 0.08), consistent with the known relationship between CD56 negativity and aggressive MM biology.

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However, the difference between the MDM2-positive and MDM2-negative groups did not reach statistical significance.

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