High-risk subgroup and associated genes identified by next generation sequencing in diffuse large B cell lymphoma.

Intriguingly, MCD tumors within Cluster 2 showed significantly poorer OS and a strong trend toward worse PFS ( p = 0.06) compared to MCD tumors in Cluster 1, while EZB cases did not show such differences.

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6 A), whereas PFS showed a clear trend toward worse outcomes in the unclassified group (Fig. 6 B).

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In both analyses, the unclassified subtype did not reach statistical significance for either OS or PFS.

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Although the unclassified subtype lacks a defined biological identity in current classification systems, our findings suggest that, within this single-center cohort, Unclassified subtype clustered exclusively within the high-risk group and showed a trend toward inferior PFS.

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Importantly, patients in Cluster 2 also had more adverse clinical features, including higher Ann Arbor stage and IPI, with elevated LDH levels trending toward significance.

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