Early Recurrence of HCC Is Driven by Inflammation-Related HIF-1α Independent Angiogenesis Rather than Hypoxia-Induced Immune Escape.

Biomolecules · 2026 · PMC13204095 · PMID 42194070

Europe PMC DOI

hedged sentences

0.0520

closest p · 1.0× alpha

0.0520

boldest claim

The sentences

a strong trendp = 0.052so close (0.05 < p ≤ 0.1)

borderline significancep = 0.052so close (0.05 < p ≤ 0.1)

At ≤6 months, MVI emerged as the dominant factor with a strong trend despite borderline significance ( p = 0.052), supporting the concept that very early recurrence primarily reflects pre-existing micrometastatic disease.

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showed a trendno p-value reported

Microvascular invasion showed a trend toward increased risk, approaching statistical significance.

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near-significantno p-value reported

Overall, none of the clinical variables were significantly associated with early recurrence, except for microvascular invasion, which demonstrated a near-significant association.

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did not reach statistical significanceno p-value reported

Patients with early recurrence were generally younger and had larger tumors, although these differences did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.