Southern Iran tertiary-center validation of 5-year disease free survival and overall survival rates in tongue squamous cell carcinoma: a confirmatory retrospective 10-years cohort study.

BMC Oral Health · 2026 · PMC13285386 · PMID 42045891

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0670

boldest claim

The sentences

did not reach statistical significanceP > 0.05actually significant

39.1%), this did not reach statistical significance ( P > 0.05) (Table 2 ).

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approaching significanceP = 0.061so close (0.05 < p ≤ 0.1)

Multivariate analysis revealed that heart disease (HR 1.94, 95% CI 1.070–6.793, P = 0.035), T-stage (HR 1.94, 95% CI 1.340–2.840, P < 0.001), and N-stage (HR 1.73, 95% CI 1.102–2.739, P = 0.017) were independent prognostic factors for DFS, with age approaching significance ( P = 0.061).

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showed a trendP = 0.067so close (0.05 < p ≤ 0.1)

For OS, age (HR 1.66, 95% CI 1.098–2.524, P = 0.016), heart disease (HR 2.64, 95% CI 1.043–6.688, P = 0.040), and T-stage (HR 2.21, 95% CI 1.476–3.313, P < 0.001) were independent prognostic factors, while N-stage showed a trend ( P = 0.067) (Table 3 ).

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a strong trend toward significanceno p-value reported

Although nodal stage (N-stage) was significantly associated with DFS and showed a strong trend toward significance for OS, other variables—including perineural invasion, lymphovascular invasion, tumor grade, and patient gender—did not retain independent prognostic value in the final model.

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